YES1
Gene Ontology Biological Process
- cell differentiation [IBA]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to platelet-derived growth factor stimulus [IDA]
- cellular response to retinoic acid [IDA]
- cellular response to transforming growth factor beta stimulus [IGI]
- glucose transport [IDA]
- innate immune response [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- protein autophosphorylation [ISO]
- regulation of cell proliferation [IBA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KHDRBS1
Gene Ontology Biological Process
- cell surface receptor signaling pathway [IDA, ISO]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of RNA export from nucleus [ISO]
- positive regulation of signal transduction [IPI]
- positive regulation of translational initiation [ISO]
- regulation of RNA export from nucleus [IDA]
Gene Ontology Molecular Function
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, phosphatidylinositol 3-kinase, and Rac.
Tissue factor (TF), apart from activating the extrinsic pathway of the blood coagulation, is a principal regulator of embryonic angiogenesis and oncogenic neoangiogenesis, but also influences inflammation, leukocyte diapedesis and tumor progression. The intracellular domain of TF lacks homology to other classes of receptors and hence the signaling mechanism is poorly understood. Here we demonstrate that factor VIIa (the natural ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 3.
Curated By
- BioGRID