BAIT
TOLLIP
toll interacting protein
GO Process (5)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
GNB2L1
RACK1, rCG_34190
guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1
GO Process (27)
GO Function (10)
GO Component (12)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of Wnt signaling pathway [ISS]
- negative regulation of cell growth [ISO, ISS]
- negative regulation of gene expression [ISO]
- negative regulation of hydrogen peroxide-induced neuron death [ISO]
- negative regulation of phagocytosis [ISO, ISS]
- negative regulation of protein kinase B signaling [ISO]
- negative regulation of protein tyrosine kinase activity [ISO]
- negative regulation of translation [IMP]
- osteoblast differentiation [IDA]
- positive regulation of GTPase activity [ISO, ISS]
- positive regulation of apoptotic process [ISO, ISS]
- positive regulation of cAMP catabolic process [ISO]
- positive regulation of cell migration [ISO, ISS]
- positive regulation of cyclic-nucleotide phosphodiesterase activity [ISO]
- positive regulation of gastrulation [ISS]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of mitochondrial depolarization [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of protein homooligomerization [ISO, ISS]
- positive regulation of protein phosphorylation [ISO, ISS]
- protein kinase C-activating G-protein coupled receptor signaling pathway [TAS]
- regulation of cell cycle [ISO, ISS]
- regulation of cell division [ISS]
- regulation of establishment of cell polarity [ISS]
- regulation of establishment of protein localization to plasma membrane [IMP]
- regulation of protein localization [ISS]
Gene Ontology Molecular Function- SH2 domain binding [ISO, ISS]
- cysteine-type endopeptidase activator activity involved in apoptotic process [ISO]
- enzyme binding [ISO]
- ion channel inhibitor activity [ISO]
- poly(A) RNA binding [ISO]
- protein homodimerization activity [ISO]
- protein kinase C binding [IC, IDA, ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase inhibitor activity [ISO, ISS]
- receptor tyrosine kinase binding [ISO, ISS]
- SH2 domain binding [ISO, ISS]
- cysteine-type endopeptidase activator activity involved in apoptotic process [ISO]
- enzyme binding [ISO]
- ion channel inhibitor activity [ISO]
- poly(A) RNA binding [ISO]
- protein homodimerization activity [ISO]
- protein kinase C binding [IC, IDA, ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase inhibitor activity [ISO, ISS]
- receptor tyrosine kinase binding [ISO, ISS]
Gene Ontology Cellular Component
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Tollip is a mediator of protein sumoylation.
Tollip is an interactor of the interleukin-1 receptor involved in its activation. The endosomal turnover of ubiquitylated IL-1RI is also controlled by Tollip. Furthermore, together with Tom1, Tollip has a general role in endosomal protein traffic. This work shows that Tollip is involved in the sumoylation process. Using the yeast two-hybrid technique, we have isolated new Tollip partners including two ... [more]
PLoS ONE Feb. 10, 2009; 4(2);e4404 [Pubmed: 19198660]
Throughput
- High Throughput
Additional Notes
- table 1.
Curated By
- BioGRID