RND2
Gene Ontology Biological Process
Gene Ontology Molecular Function
RGS14
Gene Ontology Biological Process
- cell division [IMP]
- chromosome segregation [ISS]
- intracellular signal transduction [ISS]
- learning [ISS]
- long-term memory [ISS]
- long-term synaptic potentiation [ISS]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of synaptic plasticity [ISS]
- nucleocytoplasmic transport [ISS]
- platelet-derived growth factor receptor signaling pathway [ISS]
- positive regulation of GTPase activity [IBA, IDA, TAS]
- positive regulation of neurogenesis [ISS]
- regulation of DNA-templated transcription in response to stress [ISS]
- regulation of G-protein coupled receptor protein signaling pathway [TAS]
- response to oxidative stress [ISS]
- spindle organization [IMP]
- visual learning [ISS]
- zygote asymmetric cell division [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The GTPase-deficient Rnd proteins are stabilized by their effectors.
Rnd proteins are Rho family GTP binding proteins with cellular functions that antagonize RhoA signaling. We recently described a new Rnd3 effector Syx, also named PLEKHG5 that interacts with Rnds via a Raf1-like 'Ras binding domain'. Syx is a multi-domain RhoGEF that participates in early zebrafish development. Here we demonstrated that Rnd1, Rnd2 and Rnd3 stability is acutely dependent on ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 5C.
Curated By
- BioGRID