BAIT
ALS2
3222402C23Rik, 9430073A21Rik, Als2cr6, Alsin, mKIAA1563
amyotrophic lateral sclerosis 2 (juvenile)
GO Process (21)
GO Function (11)
GO Component (20)
Gene Ontology Biological Process
- Rac protein signal transduction [ISO]
- axonogenesis [ISO]
- behavioral fear response [IMP]
- cell death [ISO]
- endosomal transport [IMP]
- endosome organization [ISO]
- locomotory behavior [IMP]
- lysosomal transport [ISO]
- neuromuscular junction development [IMP]
- neuron projection morphogenesis [ISO]
- positive regulation of Rab GTPase activity [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- protein homooligomerization [ISO]
- protein localization [IMP]
- receptor recycling [IMP]
- regulation of Rab GTPase activity [IDA]
- response to oxidative stress [IMP]
- synaptic transmission, glutamatergic [IMP]
- vesicle organization [IDA]
Gene Ontology Molecular Function- Rab GTPase activator activity [ISO]
- Rab GTPase binding [ISO]
- Rab guanyl-nucleotide exchange factor activity [ISO]
- Rac GTPase activator activity [ISO]
- Rac GTPase binding [ISO]
- Rac guanyl-nucleotide exchange factor activity [ISO]
- guanyl-nucleotide exchange factor activity [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activator activity [ISO]
- Rab GTPase activator activity [ISO]
- Rab GTPase binding [ISO]
- Rab guanyl-nucleotide exchange factor activity [ISO]
- Rac GTPase activator activity [ISO]
- Rac GTPase binding [ISO]
- Rac guanyl-nucleotide exchange factor activity [ISO]
- guanyl-nucleotide exchange factor activity [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activator activity [ISO]
Gene Ontology Cellular Component
- axon [ISO]
- cell [IMP]
- centrosome [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- dendrite [ISO]
- dendritic spine [IDA]
- early endosome [ISO]
- growth cone [ISO]
- intracellular [IMP]
- intracellular membrane-bounded organelle [ISO]
- lamellipodium [IDA]
- membrane [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- postsynaptic density [IDA]
- protein complex [ISO]
- ruffle [IDA]
- vesicle [ISO]
Mus musculus
PREY
SOD1
B430204E11Rik, Cu/Zn-SOD, CuZnSOD, Ipo-1, Ipo1, SODC, Sod-1
superoxide dismutase 1, soluble
GO Process (50)
GO Function (9)
GO Component (22)
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- aging [IMP]
- anterograde axon cargo transport [IMP]
- auditory receptor cell stereocilium organization [IMP]
- cell aging [ISO]
- cellular iron ion homeostasis [IMP]
- embryo implantation [IMP]
- glutathione metabolic process [IMP]
- heart contraction [IMP, ISO]
- hydrogen peroxide biosynthetic process [IMP, ISO]
- locomotory behavior [IMP]
- muscle cell cellular homeostasis [IMP]
- myeloid cell homeostasis [IGI, IMP]
- negative regulation of apoptotic process [IDA, IMP, ISO]
- negative regulation of cholesterol biosynthetic process [ISO]
- negative regulation of neuron apoptotic process [IMP]
- neurofilament cytoskeleton organization [IGI, IMP]
- ovarian follicle development [IMP]
- oxidation-reduction process [IMP]
- peripheral nervous system myelin maintenance [IMP]
- positive regulation of catalytic activity [ISO]
- positive regulation of cytokine production [ISO]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- positive regulation of superoxide anion generation [ISO]
- reactive oxygen species metabolic process [ISO]
- regulation of Rac GTPase activity [ISO]
- regulation of blood pressure [IMP]
- regulation of mitochondrial membrane potential [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of protein kinase activity [ISO]
- relaxation of vascular smooth muscle [IMP]
- removal of superoxide radicals [IDA, IGI, IMP, ISO, TAS]
- response to axon injury [IMP]
- response to copper ion [ISO]
- response to drug [IMP]
- response to ethanol [IMP]
- response to heat [IMP]
- response to hydrogen peroxide [IMP]
- response to nutrient levels [ISO]
- response to organic substance [ISO]
- response to oxidative stress [IDA, IMP, ISO]
- response to reactive oxygen species [IMP]
- response to superoxide [IMP, ISO]
- retina homeostasis [IMP]
- retrograde axon cargo transport [IMP]
- sensory perception of sound [IMP]
- spermatogenesis [IMP]
- superoxide anion generation [IDA]
- superoxide metabolic process [IMP, ISO]
- transmission of nerve impulse [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell [IMP]
- cytoplasm [ISO, TAS]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- dendrite cytoplasm [ISO]
- dense core granule [ISO]
- extracellular matrix [ISO]
- extracellular region [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IMP]
- mitochondrial intermembrane space [ISO]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- peroxisome [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- secretory granule [ISO]
Mus musculus
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking.
ALS2/alsin is a guanine nucleotide exchange factor for the small GTPase Rab5 and involved in macropinocytosis-associated endosome fusion and trafficking, and neurite outgrowth. ALS2 deficiency accounts for a number of juvenile recessive motor neuron diseases (MNDs). Recently, it has been shown that ALS2 plays a role in neuroprotection against MND-associated pathological insults, such as toxicity induced by mutant Cu/Zn superoxide ... [more]
PLoS ONE Mar. 27, 2010; 5(3);e9805 [Pubmed: 20339559]
Throughput
- Low Throughput
Additional Notes
- figure 1c.
- figure 2.Loss of ALS2 aggravates motor dysfunction in SOD1-H46R mice.
Curated By
- BioGRID