HGS
Gene Ontology Biological Process
- endosomal transport [NAS, TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- membrane invagination [IMP]
- membrane organization [TAS]
- negative regulation of JAK-STAT cascade [IDA]
- negative regulation of cell proliferation [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- positive regulation of exosomal secretion [IMP]
- positive regulation of gene expression [IMP]
- protein localization to membrane [IMP]
- protein targeting to lysosome [IMP]
- regulation of protein catabolic process [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BST2
Gene Ontology Biological Process
- cell proliferation [TAS]
- cell-cell signaling [TAS]
- defense response to virus [IDA]
- humoral immune response [TAS]
- innate immune response [IDA]
- multicellular organismal development [TAS]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of intracellular transport of viral material [IDA]
- negative regulation of plasmacytoid dendritic cell cytokine production [IDA]
- negative regulation of viral genome replication [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- regulation of actin cytoskeleton organization [ISS]
- response to interferon-alpha [ISS]
- response to interferon-beta [ISS]
- response to interferon-gamma [ISS]
- response to virus [IDA]
- signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation.
The Endosomal Sorting Complexes Required for Transport (ESCRT) machinery, a highly conserved set of four hetero-oligomeric protein complexes, is required for multivesicular body formation, sorting ubiquitinylated membrane proteins for lysosomal degradation, cytokinesis and the final stages of assembly of a number of enveloped viruses, including the human immunodeficiency viruses. Here, we show an additional role for the ESCRT machinery in ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 10.
Curated By
- BioGRID