SH3KBP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
INPP5D
Gene Ontology Biological Process
- dephosphorylation [IDA]
- determination of adult lifespan [IMP]
- immunoglobulin mediated immune response [IMP]
- intracellular signal transduction [IMP]
- negative regulation of B cell activation [IMP]
- negative regulation of B cell proliferation [IMP]
- negative regulation of bone resorption [IMP]
- negative regulation of cell proliferation [IDA]
- negative regulation of granulocyte differentiation [IMP]
- negative regulation of immune response [IMP]
- negative regulation of interleukin-6 biosynthetic process [IMP]
- negative regulation of monocyte differentiation [IMP]
- negative regulation of neutrophil differentiation [IMP]
- negative regulation of osteoclast differentiation [IMP]
- negative regulation of signal transduction [IMP]
- positive regulation of B cell differentiation [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of lymphocyte differentiation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CIN85 interacting proteins in B cells-specific role for SHIP-1.
The Cbl-interacting 85-kDa protein (CIN85) plays an important role as a negative regulator of signaling pathways induced by receptor tyrosine kinases. By assembling multiprotein complexes this versatile adaptor enhances receptor tyrosine kinase-activated clathrin-mediated endocytosis and reduces phosphatidylinositol-3-kinase-induced phosphatidylinositol-3,4,5-trisphosphate production. Here we report the expression of CIN85 in primary splenic B lymphocytes and the B-lymphoma cell lines WEHI 231 and Ba/F3. ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 6.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SH3KBP1 INPP5D | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | 693215 |
Curated By
- BioGRID