BAIT
CLIP3
CLIPR-59, CLIPR59, RSNL1
CAP-GLY domain containing linker protein 3
GO Process (10)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- chaperone-mediated protein transport [IMP]
- fat cell differentiation [ISS]
- membrane biogenesis [IMP]
- negative regulation of microtubule polymerization [IMP]
- peptidyl-L-cysteine S-palmitoylation [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of endocytosis [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of glucose transport [ISS]
- positive regulation of protein phosphorylation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TNFRSF21
BM-018, CD358, DR6, UNQ437/PRO868
tumor necrosis factor receptor superfamily, member 21
GO Process (18)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- B cell apoptotic process [ISS]
- T cell receptor signaling pathway [ISS]
- adaptive immune response [ISS]
- apoptotic process [IMP]
- cellular lipid metabolic process [TAS]
- cellular response to tumor necrosis factor [IDA]
- humoral immune response [ISS]
- myelination [ISS]
- negative regulation of B cell proliferation [ISS]
- negative regulation of T cell proliferation [ISS]
- negative regulation of interleukin-10 secretion [ISS]
- negative regulation of interleukin-13 secretion [ISS]
- negative regulation of interleukin-5 secretion [ISS]
- negative regulation of myelination [IMP]
- neuron apoptotic process [ISS]
- oligodendrocyte apoptotic process [ISS]
- regulation of oligodendrocyte differentiation [ISS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
CLIPR-59 regulates TNF-α-induced apoptosis by controlling ubiquitination of RIP1.
Tumor necrosis factor-α (TNF-α) has important roles in several immunological events by regulating apoptosis and transcriptional activation of cytokine genes. Intracellular signaling mediated by TNF-receptor-type 1 (TNFR1) is constituted by two sequential protein complexes: Complex-I containing the receptor and Complex-II-containing Caspase-8. Protein modifications, particularly ubiquitination, are associated with the regulation of the formation of these complexes. However, the underlying mechanisms ... [more]
Cell Death Dis Feb. 03, 2012; 3(0);e264 [Pubmed: 22297296]
Throughput
- Low Throughput
Curated By
- BioGRID