FADD
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell differentiation in thymus [ISS]
- T cell homeostasis [ISS]
- TRAIL-activated apoptotic signaling pathway [IDA]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of cysteine-type endopeptidase activity [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- apoptotic process [IMP, TAS]
- apoptotic signaling pathway [IDA, TAS]
- cellular response to mechanical stimulus [IEP]
- defense response to virus [IMP]
- extrinsic apoptotic signaling pathway [IDA, IMP, TAS]
- extrinsic apoptotic signaling pathway via death domain receptors [TAS]
- innate immune response [TAS]
- lymph node development [ISS]
- necroptotic signaling pathway [IMP]
- negative regulation of activation-induced cell death of T cells [ISS]
- positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of T cell mediated cytotoxicity [ISS]
- positive regulation of activated T cell proliferation [ISS]
- positive regulation of adaptive immune response [ISS]
- positive regulation of apoptotic process [IMP]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of interferon-gamma production [ISS]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of macrophage differentiation [IMP]
- positive regulation of proteolysis [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor production [IDA]
- positive regulation of type I interferon-mediated signaling pathway [IMP]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- spleen development [ISS]
- thymus development [ISS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CLIP3
Gene Ontology Biological Process
- chaperone-mediated protein transport [IMP]
- fat cell differentiation [ISS]
- membrane biogenesis [IMP]
- negative regulation of microtubule polymerization [IMP]
- peptidyl-L-cysteine S-palmitoylation [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of endocytosis [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of glucose transport [ISS]
- positive regulation of protein phosphorylation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CLIPR-59 regulates TNF-α-induced apoptosis by controlling ubiquitination of RIP1.
Tumor necrosis factor-α (TNF-α) has important roles in several immunological events by regulating apoptosis and transcriptional activation of cytokine genes. Intracellular signaling mediated by TNF-receptor-type 1 (TNFR1) is constituted by two sequential protein complexes: Complex-I containing the receptor and Complex-II-containing Caspase-8. Protein modifications, particularly ubiquitination, are associated with the regulation of the formation of these complexes. However, the underlying mechanisms ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID