CDH1
Gene Ontology Biological Process
- adherens junction organization [ISO]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- cellular response to amino acid stimulus [IDA]
- cellular response to indole-3-methanol [ISO]
- cellular response to lithium ion [ISO]
- cochlea development [IMP]
- epithelial cell morphogenesis [IMP]
- establishment of protein localization to plasma membrane [IDA, ISO]
- in utero embryonic development [IMP]
- intestinal epithelial cell development [IMP]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of epithelial cell proliferation [IMP]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein homooligomerization [IDA]
- protein localization to plasma membrane [ISO]
- protein metabolic process [IDA]
- regulation of branching involved in salivary gland morphogenesis [IMP]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- regulation of neuron migration [IDA]
- regulation of protein localization [IMP]
- regulation of protein localization to cell surface [IMP]
- regulation of water loss via skin [IMP]
- salivary gland cavitation [IMP]
- sensory perception of sound [IMP]
- single organismal cell-cell adhesion [IMP, ISO]
- synapse assembly [ISO]
- tight junction assembly [IMP]
- trophectodermal cell differentiation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [IDA]
- actin cytoskeleton [ISO]
- adherens junction [IDA]
- aggresome [ISO]
- apical junction complex [IDA, ISO]
- apical part of cell [IDA]
- axon [IDA]
- axon terminus [IDA]
- basolateral plasma membrane [IDA]
- catenin complex [IDA, ISO]
- cell junction [ISO]
- cell periphery [IDA]
- cell surface [IDA]
- cell-cell adherens junction [IDA, ISO]
- cell-cell junction [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic side of plasma membrane [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- integral component of membrane [ISO]
- lateral loop [IDA]
- lateral plasma membrane [ISO]
- node of Ranvier [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- trans-Golgi network [ISO]
DNMT1
Gene Ontology Biological Process
- C-5 methylation of cytosine [IDA]
- DNA hypermethylation [ISO]
- DNA methylation [IDA, IMP]
- DNA methylation on cytosine [ISO]
- DNA methylation on cytosine within a CG sequence [ISO]
- S-adenosylhomocysteine metabolic process [ISO]
- S-adenosylmethioninamine metabolic process [ISO]
- S-adenosylmethionine metabolic process [ISO]
- cellular response to amino acid stimulus [IDA]
- cellular response to transforming growth factor beta stimulus [ISO]
- gene silencing [IDA]
- maintenance of DNA methylation [IMP, ISO]
- negative regulation of histone H3-K9 methylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of gene expression [ISO]
- positive regulation of histone H3-K4 methylation [ISO]
- regulation of cell proliferation [IGI]
- regulation of gene expression [IMP]
- response to antidepressant [ISO]
Gene Ontology Molecular Function- DNA (cytosine-5-)-methyltransferase activity [IDA, ISO]
- DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [ISO]
- DNA binding [IDA, ISO]
- DNA-methyltransferase activity [ISO]
- RNA binding [IDA]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- estrogen receptor binding [ISO]
- histone deacetylase binding [ISO]
- methyl-CpG binding [IDA, ISO]
- methyltransferase activity [IDA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- unmethylated CpG binding [ISO]
- zinc ion binding [IDA]
- DNA (cytosine-5-)-methyltransferase activity [IDA, ISO]
- DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [ISO]
- DNA binding [IDA, ISO]
- DNA-methyltransferase activity [ISO]
- RNA binding [IDA]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- estrogen receptor binding [ISO]
- histone deacetylase binding [ISO]
- methyl-CpG binding [IDA, ISO]
- methyltransferase activity [IDA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- unmethylated CpG binding [ISO]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal.
5-Azacytidine- and 5-aza-deoxycytidine (5-aza-CdR)-mediated reactivation of tumor suppressor genes silenced by promoter methylation has provided an alternate approach in cancer therapy. Despite the importance of epigenetic therapy, the mechanism of action of DNA-hypomethylating agents in vivo has not been completely elucidated. Here we report that among three functional DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B), the maintenance methyltransferase, DNMT1, was rapidly ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 7F.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DNMT1 CDH1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 695256 |
Curated By
- BioGRID