LNX1
Gene Ontology Molecular Function
ABCA1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP]
- apolipoprotein A-I-mediated signaling pathway [IDA]
- cellular lipid metabolic process [TAS]
- cholesterol efflux [IDA, IMP]
- cholesterol homeostasis [IDA]
- cholesterol metabolic process [IDA]
- endosomal transport [IDA]
- high-density lipoprotein particle assembly [IMP]
- interleukin-1 beta secretion [IMP]
- intracellular cholesterol transport [IMP]
- lipoprotein metabolic process [TAS]
- lysosome organization [IDA]
- negative regulation of cholesterol storage [TAS]
- negative regulation of macrophage derived foam cell differentiation [TAS]
- phospholipid efflux [IDA, IMP]
- phospholipid homeostasis [IMP]
- platelet dense granule organization [IMP]
- positive regulation of cAMP biosynthetic process [IMP]
- regulation of Cdc42 protein signal transduction [IMP]
- response to laminar fluid shear stress [IEP]
- response to low-density lipoprotein particle [IEP]
- reverse cholesterol transport [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase binding [IPI]
- anion transmembrane transporter activity [ISS]
- apolipoprotein A-I binding [IPI]
- apolipoprotein A-I receptor activity [IDA]
- apolipoprotein binding [IPI]
- cholesterol binding [IC]
- cholesterol transporter activity [IDA]
- phospholipid binding [IC]
- phospholipid transporter activity [IDA]
- protein binding [IPI]
- receptor binding [IPI]
- small GTPase binding [IPI]
- syntaxin binding [IPI]
- ATP binding [IDA]
- ATPase binding [IPI]
- anion transmembrane transporter activity [ISS]
- apolipoprotein A-I binding [IPI]
- apolipoprotein A-I receptor activity [IDA]
- apolipoprotein binding [IPI]
- cholesterol binding [IC]
- cholesterol transporter activity [IDA]
- phospholipid binding [IC]
- phospholipid transporter activity [IDA]
- protein binding [IPI]
- receptor binding [IPI]
- small GTPase binding [IPI]
- syntaxin binding [IPI]
Gene Ontology Cellular Component
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Proteomics Strategy to Identify Substrates of LNX, a PDZ Domain-containing E3 Ubiquitin Ligase.
Ubiquitin ligases (E3s) confer specificity to ubiquitination by recognizing target substrates. However, the substrates of most E3s have not been extensively discovered, and new methods are needed to efficiently and comprehensively identify these substrates. Mostly, E3s specifically recognize substrates via their protein interaction domains. We developed a novel integrated strategy to identify substrates of E3s containing protein interaction domains on ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 4.
Curated By
- BioGRID