LNX1
Gene Ontology Molecular Function
HTR2B
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IMP]
- G-protein coupled receptor signaling pathway [IMP]
- activation of phospholipase C activity [IDA]
- cGMP biosynthetic process [IDA]
- calcium-mediated signaling [IMP]
- cardiac muscle hypertrophy [ISS]
- cellular calcium ion homeostasis [IDA]
- cellular response to temperature stimulus [ISS]
- embryonic morphogenesis [ISS]
- heart morphogenesis [ISS]
- intestine smooth muscle contraction [IMP]
- negative regulation of apoptotic process [ISS]
- negative regulation of autophagy [IMP]
- negative regulation of cell death [IMP]
- neural crest cell differentiation [ISS]
- neural crest cell migration [ISS]
- phosphatidylinositol 3-kinase signaling [IDA]
- phosphorylation [IMP]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of cell division [ISS]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of cytokine production [IDA]
- positive regulation of cytokine secretion [ISS]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of phosphatidylinositol biosynthetic process [IDA]
- protein kinase C signaling [IMP]
- protein kinase C-activating G-protein coupled receptor signaling pathway [ISS]
- regulation of behavior [IMP]
- release of sequestered calcium ion into cytosol [IDA, IMP]
- response to drug [IDA]
- serotonin receptor signaling pathway [IMP]
- vasoconstriction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Proteomics Strategy to Identify Substrates of LNX, a PDZ Domain-containing E3 Ubiquitin Ligase.
Ubiquitin ligases (E3s) confer specificity to ubiquitination by recognizing target substrates. However, the substrates of most E3s have not been extensively discovered, and new methods are needed to efficiently and comprehensively identify these substrates. Mostly, E3s specifically recognize substrates via their protein interaction domains. We developed a novel integrated strategy to identify substrates of E3s containing protein interaction domains on ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 4.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LNX1 HTR2B | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | 695323 |
Curated By
- BioGRID