BAIT
ADRA2C
ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR
adrenoceptor alpha 2C
GO Process (13)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- activation of MAPK activity by adrenergic receptor signaling pathway [IDA]
- activation of protein kinase B activity [IDA]
- blood coagulation [TAS]
- cell-cell signaling [TAS]
- energy reserve metabolic process [TAS]
- epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway [IDA]
- negative regulation of epinephrine secretion [NAS]
- negative regulation of norepinephrine secretion [NAS, TAS]
- platelet activation [TAS]
- positive regulation of neuron differentiation [IDA]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
UCHL1
HEL-117, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
GO Process (3)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation.
Neuroprotective effects of alpha(2)-adrenergic receptor (AR) agonists are mediated via the alpha(2A)AR subtype, but the molecular mechanisms underlying these actions are still not elucidated. A two-hybrid screen was performed to identify new proteins that may control alpha(2)AR receptor function and trafficking. This screen identified the ubiquitin carboxyl-terminal hydrolase-L1 (Uch-L1), a protein associated with Parkinson's disease, as alpha(2)AR interacting protein. This ... [more]
Cell. Signal. Oct. 01, 2009; 21(10);1513-21 [Pubmed: 19477270]
Throughput
- Low Throughput
Curated By
- BioGRID