CD4
Gene Ontology Biological Process
- T cell costimulation [TAS]
- T cell differentiation [IDA]
- T cell receptor signaling pathway [TAS]
- T cell selection [IDA]
- cell surface receptor signaling pathway [TAS]
- entry into host cell [TAS]
- enzyme linked receptor protein signaling pathway [TAS]
- immune response [NAS]
- induction by virus of host cell-cell fusion [IDA]
- innate immune response [TAS]
- maintenance of protein location in cell [IDA]
- positive regulation of interleukin-2 biosynthetic process [NAS]
- positive regulation of protein kinase activity [IDA]
- protein palmitoleylation [IDA]
- regulation of T cell activation [IDA]
- regulation of defense response to virus by virus [TAS]
- signal transduction [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [NAS]
- viral process [TAS]
Gene Ontology Molecular Function- MHC class II protein binding [NAS]
- coreceptor activity [NAS]
- enzyme binding [IPI]
- extracellular matrix structural constituent [NAS]
- glycoprotein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [IPI]
- receptor activity [TAS]
- transmembrane signaling receptor activity [TAS]
- zinc ion binding [IDA]
- MHC class II protein binding [NAS]
- coreceptor activity [NAS]
- enzyme binding [IPI]
- extracellular matrix structural constituent [NAS]
- glycoprotein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [IPI]
- receptor activity [TAS]
- transmembrane signaling receptor activity [TAS]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
VCP
Gene Ontology Biological Process
- DNA repair [NAS]
- ER-associated ubiquitin-dependent protein catabolic process [IDA, IMP, TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- cellular response to DNA damage stimulus [IDA]
- double-strand break repair [IDA]
- endoplasmic reticulum unfolded protein response [TAS]
- establishment of protein localization [TAS]
- positive regulation of Lys63-specific deubiquitinase activity [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein K63-linked deubiquitination [IDA]
- positive regulation of protein catabolic process [IDA]
- positive regulation of protein complex assembly [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [NAS]
- protein N-linked glycosylation via asparagine [IMP]
- protein ubiquitination [IDA, NAS]
- regulation of apoptotic process [TAS]
- retrograde protein transport, ER to cytosol [IDA]
- translesion synthesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Hrd1p ubiquitin ligase complex [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- endoplasmic reticulum [IDA]
- endoplasmic reticulum membrane [IDA]
- extracellular vesicular exosome [IDA]
- intracellular membrane-bounded organelle [ISS]
- lipid particle [IDA]
- nucleoplasm [IDA]
- nucleus [IDA, TAS]
- perinuclear region of cytoplasm [IDA]
- proteasome complex [IDA]
- site of double-strand break [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
The transmembrane domains (TMDs) of integral membrane proteins do not merely function as membrane anchors but play active roles in many important biological processes. The downregulation of the CD4 coreceptor by the Vpu protein of HIV-1 is a prime example of a process that is dependent on specific properties of TMDs. Here we report the identification of Trp22 in the ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 3.
Curated By
- BioGRID