ADRBK1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA, ISO]
- cardiac muscle contraction [ISO]
- desensitization of G-protein coupled receptor protein signaling pathway [IGI, IMP, ISO]
- follicle-stimulating hormone signaling pathway [ISO]
- heart development [IMP]
- negative regulation of G-protein coupled receptor protein signaling pathway [ISO]
- negative regulation of striated muscle contraction [ISO]
- negative regulation of the force of heart contraction by chemical signal [ISO]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of catecholamine secretion [ISO]
- protein phosphorylation [IDA, IMP, ISO]
- receptor internalization [ISO]
- regulation of the force of heart contraction [IGI]
- response to organic cyclic compound [ISO]
- response to oxidative stress [ISO]
- tachykinin receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SCNN1B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2.
Epithelial Na(+) channels (ENaC) mediate the transport of sodium (Na) across epithelia in the kidney, gut, and lungs and are required for blood pressure regulation. They are inhibited by ubiquitin protein ligases, such as Nedd4 and Nedd4-2, which bind to proline-rich motifs (PY motifs) present in the C-termini of ENaC subunits. Loss of inhibition leads to hypertension. ENaC channels are ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID