BAIT

GZMK

TRYP2
granzyme K (granzyme 3; tryptase II)
GO Process (0)
GO Function (1)
GO Component (0)

Gene Ontology Molecular Function

Homo sapiens
PREY

UFD1L

UFD1
ubiquitin fusion degradation 1 like (yeast)
UPS Project
GO Process (2)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Biochemical Activity (Proteolytic Processing)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Valosin-containing protein cleavage by granzyme K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target tumor cells.

Guo Y, Chen J, Shi L, Fan Z

Granzyme K (GzmK) highly expressed in NK and NKT cells. We recently demonstrated that GzmK induces rapid caspase-independent cell death with ssDNA nicks. Little is known about its molecular mechanisms to mediate caspase-independent cell death. In this study, we found the valosin-containing protein (VCP) is a physiological substrate of GzmK. GzmK cleaves VCP at residue Arg(713) in the D2 domain ... [more]

J. Immunol. Nov. 01, 2010; 185(9);5348-59 [Pubmed: 20876349]

Throughput

  • Low Throughput

Curated By

  • BioGRID