MDM2
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [IMP, TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- cellular response to hypoxia [IEP]
- epidermal growth factor receptor signaling pathway [TAS]
- establishment of protein localization [IDA]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of cell cycle arrest [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-lysine modification [IMP]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of cell proliferation [TAS]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- protein complex assembly [IDA]
- protein destabilization [IDA]
- protein localization to nucleus [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- regulation of protein catabolic process [IDA]
- response to antibiotic [IEP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ANG
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis [IDA]
- actin filament polymerization [ISS]
- activation of phospholipase A2 activity [IMP]
- activation of phospholipase C activity [IMP]
- activation of protein kinase B activity [IMP]
- angiogenesis [IDA, IMP, TAS]
- cell communication [NAS]
- cell migration [IMP]
- diacylglycerol biosynthetic process [IDA]
- homeostatic process [NAS]
- negative regulation of smooth muscle cell proliferation [IDA]
- nucleic acid phosphodiester bond hydrolysis [TAS]
- oocyte maturation [NAS]
- ovarian follicle development [NAS]
- placenta development [NAS]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of phosphorylation [IDA]
- positive regulation of protein secretion [IDA, ISS]
- rRNA transcription [IMP]
- response to hormone [IDA]
- response to hypoxia [IDA, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Angiogenin functionally interacts with p53 and regulates p53-mediated apoptosis and cell survival.
Angiogenin, a 14-kDa multifunctional pro-angiogenic growth factor, is upregulated in several types of cancers. Anti-angiogenin monoclonal antibodies used as antagonists inhibited the establishment, progression and metastasis of human cancer cells in athymic mice (Olson et al., 1994). Silencing angiogenin and inhibition of angiogenin's nuclear translocation blocked cell survival and induced cell death in B-lymphoma and endothelial cells latently infected with ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID