BAIT
VCP
valosin-containing protein
GO Process (19)
GO Function (13)
GO Component (15)
Gene Ontology Biological Process
- ATP catabolic process [IDA, IMP]
- ER to Golgi vesicle-mediated transport [IMP]
- ER-associated ubiquitin-dependent protein catabolic process [ISO, ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- aggresome assembly [ISO]
- cellular response to DNA damage stimulus [ISO, ISS]
- double-strand break repair [ISO, ISS]
- positive regulation of Lys63-specific deubiquitinase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP, ISO]
- positive regulation of protein K63-linked deubiquitination [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein complex assembly [ISO]
- protein N-linked glycosylation via asparagine [ISO, ISS]
- protein hexamerization [IDA]
- protein homooligomerization [IDA]
- protein ubiquitination [ISO, ISS]
- retrograde protein transport, ER to cytosol [ISO]
- translesion synthesis [ISO, ISS]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function- ADP binding [IMP]
- ATP binding [IDA, IMP]
- ATPase activity [IDA, IMP]
- deubiquitinase activator activity [ISO]
- identical protein binding [IDA]
- poly(A) RNA binding [ISO]
- polyubiquitin binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [IDA]
- ubiquitin-specific protease binding [ISO]
- ADP binding [IMP]
- ATP binding [IDA, IMP]
- ATPase activity [IDA, IMP]
- deubiquitinase activator activity [ISO]
- identical protein binding [IDA]
- poly(A) RNA binding [ISO]
- polyubiquitin binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [IDA]
- ubiquitin-specific protease binding [ISO]
Gene Ontology Cellular Component
- Hrd1p ubiquitin ligase complex [ISO]
- cytoplasm [ISO]
- cytosol [IDA, ISO]
- endoplasmic reticulum [IDA, ISO]
- endoplasmic reticulum membrane [ISO]
- extracellular vesicular exosome [ISO]
- intracellular membrane-bounded organelle [IDA]
- lipid particle [ISO]
- myelin sheath [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- proteasome complex [ISO]
- protein complex [ISO]
- site of double-strand break [ISO, ISS]
Rattus norvegicus
PREY
B2M
beta-2 microglobulin
GO Process (9)
GO Function (1)
GO Component (8)
Gene Ontology Biological Process
- T cell differentiation in thymus [ISO]
- antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [ISO]
- iron ion homeostasis [ISO]
- positive regulation of T cell mediated cytotoxicity [ISO]
- protein refolding [ISO]
- response to cadmium ion [IEP]
- response to drug [IEP]
- response to molecule of bacterial origin [ISO]
- retina homeostasis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains.
A member of the family of ATPases associated with diverse cellular activities, called p97 in mammals and Cdc48 in yeast, associates with the cofactor Ufd1-Npl4 to move polyubiquitinated polypeptides from the endoplasmic reticulum (ER) membrane into the cytosol for their subsequent degradation by the proteasome. Here, we have studied the mechanism by which the p97-Ufd1-Npl4 complex functions in this retrotranslocation ... [more]
J. Cell Biol. Jul. 07, 2003; 162(1);71-84 [Pubmed: 12847084]
Throughput
- Low Throughput
Additional Notes
- figure 3.
Curated By
- BioGRID