NOS2
Gene Ontology Biological Process
- arginine catabolic process [IDA]
- blood coagulation [TAS]
- defense response to Gram-negative bacterium [NAS]
- defense response to bacterium [IMP, ISS]
- inflammatory response [IBA]
- innate immune response in mucosa [NAS]
- interaction with host [TAS]
- negative regulation of blood pressure [IBA]
- negative regulation of gene expression [IGI]
- nitric oxide biosynthetic process [IDA]
- nitric oxide mediated signal transduction [IBA]
- peptidyl-cysteine S-nitrosylation [ISS]
- phagosome maturation [TAS]
- positive regulation of guanylate cyclase activity [IBA]
- positive regulation of killing of cells of other organism [IMP]
- positive regulation of leukocyte mediated cytotoxicity [TAS]
- positive regulation of vasodilation [IBA]
- regulation of cellular respiration [TAS]
- regulation of insulin secretion [IMP]
- response to bacterium [NAS]
- superoxide metabolic process [ISS]
Gene Ontology Molecular Function- FMN binding [ISS]
- NADP binding [TAS]
- NADPH-hemoprotein reductase activity [IBA]
- arginine binding [ISS]
- flavin adenine dinucleotide binding [ISS]
- heme binding [ISS]
- nitric-oxide synthase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- receptor binding [IPI]
- tetrahydrobiopterin binding [ISS]
- FMN binding [ISS]
- NADP binding [TAS]
- NADPH-hemoprotein reductase activity [IBA]
- arginine binding [ISS]
- flavin adenine dinucleotide binding [ISS]
- heme binding [ISS]
- nitric-oxide synthase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- receptor binding [IPI]
- tetrahydrobiopterin binding [ISS]
STUB1
Gene Ontology Biological Process
- cellular response to misfolded protein [IDA]
- misfolded or incompletely synthesized protein catabolic process [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- positive regulation of chaperone-mediated protein complex assembly [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein ubiquitination [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K63-linked ubiquitination [IDA]
- protein autoubiquitination [IDA]
- protein maturation [TAS]
- protein polyubiquitination [IDA, IMP]
- regulation of glucocorticoid metabolic process [IDA]
- transforming growth factor beta receptor signaling pathway [TAS]
- ubiquitin-dependent SMAD protein catabolic process [IDA]
- ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IDA]
- Hsp90 protein binding [IDA]
- SMAD binding [IDA]
- TPR domain binding [IDA]
- enzyme binding [IPI]
- kinase binding [IPI]
- misfolded protein binding [IDA]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [ISS]
- ubiquitin protein ligase activity [IDA]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA, IMP, TAS]
- ubiquitin-ubiquitin ligase activity [ISS]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IDA]
- Hsp90 protein binding [IDA]
- SMAD binding [IDA]
- TPR domain binding [IDA]
- enzyme binding [IPI]
- kinase binding [IPI]
- misfolded protein binding [IDA]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [ISS]
- ubiquitin protein ligase activity [IDA]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA, IMP, TAS]
- ubiquitin-ubiquitin ligase activity [ISS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A critical role for CHIP in the aggresome pathway.
Recent evidence suggests that aggresome formation is a physiologic stress response not limited to misfolded proteins. That stress response, termed "physiologic aggresome," is exemplified by aggresome formation of inducible nitric oxide synthase (iNOS), an important host defense protein. CHIP (carboxy terminus of Hsp70-interacting protein) is a highly conserved protein that has been shown to mediate substrate ubiquitination and degradation by ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID