BAIT
CAV3
caveolin 3
GO Process (56)
GO Function (12)
GO Component (17)
Gene Ontology Biological Process
- actin filament organization [ISO]
- cardiac muscle cell development [ISO]
- caveola assembly [ISO]
- cell differentiation [IEP]
- cell growth [IEP]
- cholesterol homeostasis [ISO]
- cytoplasmic microtubule organization [ISO]
- endocytosis [ISO]
- establishment of protein localization to plasma membrane [ISO]
- glucose homeostasis [ISO]
- heart trabecula formation [ISO]
- membrane raft organization [ISO]
- muscle cell cellular homeostasis [ISO]
- myoblast fusion [ISO]
- myotube differentiation [ISO]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of MAPK cascade [ISO]
- negative regulation of calcium ion transport [ISO]
- negative regulation of cardiac muscle hypertrophy [ISO]
- negative regulation of cell growth involved in cardiac muscle cell development [IMP]
- negative regulation of cell size [ISO]
- negative regulation of nitric-oxide synthase activity [ISO]
- negative regulation of potassium ion transmembrane transport [IMP]
- negative regulation of potassium ion transmembrane transporter activity [IMP]
- negative regulation of protein kinase activity [ISO]
- negative regulation of sarcomere organization [ISO]
- nucleus localization [ISO]
- plasma membrane organization [ISO]
- plasma membrane repair [ISO]
- positive regulation of caveolin-mediated endocytosis [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of microtubule polymerization [IMP]
- positive regulation of myotube differentiation [ISO]
- protein localization [ISO]
- protein localization to plasma membrane [ISO]
- regulation of branching involved in mammary gland duct morphogenesis [ISO]
- regulation of calcium ion import [ISO]
- regulation of calcium ion transmembrane transporter activity [ISO]
- regulation of calcium ion transport [ISO]
- regulation of cardiac muscle contraction [ISO]
- regulation of heart contraction [IMP]
- regulation of heart rate [ISO]
- regulation of membrane depolarization during cardiac muscle cell action potential [ISO]
- regulation of membrane potential [ISO]
- regulation of nerve growth factor receptor activity [ISO]
- regulation of p38MAPK cascade [ISO]
- regulation of protein kinase B signaling [ISO]
- regulation of signal transduction by receptor internalization [ISO]
- regulation of skeletal muscle contraction [ISO]
- regulation of sodium ion transmembrane transporter activity [ISO]
- regulation of transforming growth factor beta receptor signaling pathway [ISO]
- regulation of ventricular cardiac muscle cell membrane depolarization [ISO]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISO]
- triglyceride metabolic process [ISO]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function- alpha-tubulin binding [ISO]
- calcium channel regulator activity [ISO]
- connexin binding [ISO]
- enzyme binding [IPI]
- ion channel binding [IPI, ISO]
- nitric-oxide synthase binding [IPI]
- potassium channel inhibitor activity [IMP]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein complex scaffold [IDA, ISO]
- sodium channel regulator activity [ISO]
- alpha-tubulin binding [ISO]
- calcium channel regulator activity [ISO]
- connexin binding [ISO]
- enzyme binding [IPI]
- ion channel binding [IPI, ISO]
- nitric-oxide synthase binding [IPI]
- potassium channel inhibitor activity [IMP]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein complex scaffold [IDA, ISO]
- sodium channel regulator activity [ISO]
Gene Ontology Cellular Component
- T-tubule [IDA, ISO]
- Z disc [IDA]
- caveola [IDA, ISO]
- cell [ISO]
- cell surface [IDA]
- cytoplasm [IDA]
- dystrophin-associated glycoprotein complex [ISO]
- endoplasmic reticulum [ISO]
- integral component of membrane [TAS]
- intercalated disc [IDA]
- membrane [ISO]
- membrane raft [ISO]
- neuromuscular junction [IDA]
- plasma membrane [IDA, ISO]
- protein complex [IDA]
- sarcolemma [IDA, ISO]
- vesicle [IDA]
Rattus norvegicus
PREY
KCNH2
ERG1
potassium voltage-gated channel, subfamily H (eag-related), member 2
GO Process (21)
GO Function (11)
GO Component (6)
Gene Ontology Biological Process
- brain development [IEP]
- cardiac muscle contraction [ISO]
- cellular response to drug [ISO]
- membrane depolarization during action potential [ISO]
- membrane repolarization during action potential [ISO]
- membrane repolarization during cardiac muscle cell action potential [ISO]
- negative regulation of potassium ion export [ISO]
- negative regulation of potassium ion transmembrane transport [ISO]
- positive regulation of potassium ion transmembrane transport [ISO]
- potassium ion export [ISO]
- potassium ion homeostasis [ISO]
- potassium ion transmembrane transport [IBA, ISO]
- potassium ion transport [IDA]
- protein heterooligomerization [IDA]
- regulation of heart rate by cardiac conduction [IBA, ISO]
- regulation of membrane potential [IDA, ISO]
- regulation of membrane repolarization [ISO]
- regulation of potassium ion transmembrane transport [ISO]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISO]
- spinal cord development [IEP]
- ventricular cardiac muscle cell action potential [ISO]
Gene Ontology Molecular Function- delayed rectifier potassium channel activity [ISO]
- identical protein binding [ISO]
- inward rectifier potassium channel activity [IDA, ISO]
- ion channel activity [IDA]
- potassium channel activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- scaffold protein binding [IPI, ISO]
- ubiquitin protein ligase binding [ISO]
- voltage-gated potassium channel activity [IDA, ISO]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [ISO]
- delayed rectifier potassium channel activity [ISO]
- identical protein binding [ISO]
- inward rectifier potassium channel activity [IDA, ISO]
- ion channel activity [IDA]
- potassium channel activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- scaffold protein binding [IPI, ISO]
- ubiquitin protein ligase binding [ISO]
- voltage-gated potassium channel activity [IDA, ISO]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cell surface expression of hERG channels is regulated by caveolin-3 via Nedd4-2.
The human ether-a-go-go-related gene (hERG) encodes the rapidly activating delayed rectifier potassium channel (I(Kr)) which plays an important role in cardiac repolarization. A reduction or increase in hERG current can cause long or short QT syndrome, respectively, leading to fatal cardiac arrhythmias. The channel density in the plasma membrane is a key determinant of the whole cell current amplitude. To ... [more]
J. Biol. Chem. Aug. 09, 2012; 0(0); [Pubmed: 22879586]
Throughput
- Low Throughput
Curated By
- BioGRID