BHLHE41
Gene Ontology Biological Process
- cell differentiation [NAS]
- cell proliferation [NAS]
- negative regulation of myotube differentiation [ISS]
- negative regulation of transcription by competitive promoter binding [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- organ morphogenesis [NAS]
Gene Ontology Molecular Function- E-box binding [IDA, ISS]
- MRF binding [ISS]
- RNA polymerase II activating transcription factor binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [ISS]
- bHLH transcription factor binding [IPI, ISS]
- histone deacetylase binding [ISS]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISS]
- protein homodimerization activity [ISS]
- transcription corepressor activity [IDA]
- E-box binding [IDA, ISS]
- MRF binding [ISS]
- RNA polymerase II activating transcription factor binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [ISS]
- bHLH transcription factor binding [IPI, ISS]
- histone deacetylase binding [ISS]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISS]
- protein homodimerization activity [ISS]
- transcription corepressor activity [IDA]
BHLHE41
Gene Ontology Biological Process
- cell differentiation [NAS]
- cell proliferation [NAS]
- negative regulation of myotube differentiation [ISS]
- negative regulation of transcription by competitive promoter binding [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- organ morphogenesis [NAS]
Gene Ontology Molecular Function- E-box binding [IDA, ISS]
- MRF binding [ISS]
- RNA polymerase II activating transcription factor binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [ISS]
- bHLH transcription factor binding [IPI, ISS]
- histone deacetylase binding [ISS]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISS]
- protein homodimerization activity [ISS]
- transcription corepressor activity [IDA]
- E-box binding [IDA, ISS]
- MRF binding [ISS]
- RNA polymerase II activating transcription factor binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [ISS]
- bHLH transcription factor binding [IPI, ISS]
- histone deacetylase binding [ISS]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISS]
- protein homodimerization activity [ISS]
- transcription corepressor activity [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors.
The molecular determinants of malignant cell behaviours in breast cancer remain only partially understood. Here we show that SHARP1 (also known as BHLHE41 or DEC2) is a crucial regulator of the invasive and metastatic phenotype in triple-negative breast cancer (TNBC), one of the most aggressive types of breast cancer. SHARP1 is regulated by the p63 metastasis suppressor and inhibits TNBC ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BHLHE41 BHLHE41 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| BHLHE41 BHLHE41 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID