BAIT
SLC1A2
1700091C19Rik, 2900019G14Rik, AI159670, Eaat2, GLT-1, GLT1, MGLT1, RP23-163L4.1
solute carrier family 1 (glial high affinity glutamate transporter), member 2
GO Process (17)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- D-aspartate import [ISO]
- L-glutamate import [ISO]
- L-glutamate transmembrane transport [IMP, ISO]
- L-glutamate transport [IDA, IMP, ISO]
- adult behavior [IMP]
- cellular response to extracellular stimulus [IMP]
- multicellular organism growth [IMP]
- multicellular organismal aging [IMP]
- nervous system development [IMP]
- positive regulation of glucose import [IMP]
- response to amino acid [IMP]
- response to drug [IMP]
- response to light stimulus [IMP]
- response to wounding [IMP]
- sodium ion transmembrane transport [ISO]
- telencephalon development [IMP]
- visual behavior [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SUMO1
DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, UBL1, OK/SW-cl.43
small ubiquitin-like modifier 1
GO Process (14)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- DNA repair [TAS]
- cellular protein metabolic process [TAS]
- cytokine-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of DNA binding [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- palate development [ISS]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein complex assembly [IDA]
- post-translational protein modification [TAS]
- protein sumoylation [IDA, TAS]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of protein localization [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis.
EAAT2 (excitatory amino acid transporter 2) is a high affinity, Na+-dependent glutamate transporter of glial origin that is essential for the clearance of synaptically released glutamate and prevention of excitotoxicity. During the course of human amyotrophic lateral sclerosis (ALS) and in a transgenic mutant SOD1 mouse model of the disease, expression and activity of EAAT2 is remarkably reduced. We previously ... [more]
J. Biol. Chem. Nov. 02, 2007; 282(44);32480-90 [Pubmed: 17823119]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- Likely protein-protein interaction
- table 1.
Curated By
- BioGRID