BAIT
GATA4
Gata-4
GATA binding protein 4
GO Process (66)
GO Function (17)
GO Component (3)
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- SMAD protein signal transduction [IDA]
- Sertoli cell differentiation [IMP]
- atrial septum morphogenesis [ISO]
- atrial septum primum morphogenesis [IMP]
- atrial septum secundum morphogenesis [ISO]
- atrioventricular canal development [IGI]
- atrioventricular valve formation [IGI]
- atrioventricular valve morphogenesis [IGI, TAS]
- canonical Wnt signaling pathway [IDA]
- cardiac muscle cell differentiation [IGI, IMP, NAS]
- cardiac muscle hypertrophy in response to stress [IMP]
- cardiac muscle tissue development [IGI]
- cardiac right ventricle morphogenesis [IMP]
- cardiac septum development [IGI]
- cell growth involved in cardiac muscle cell development [ISO]
- cell-cell signaling [IMP]
- cellular response to follicle-stimulating hormone stimulus [IDA]
- cellular response to gonadotropin stimulus [IDA]
- diaphragm morphogenesis [TAS]
- embryonic digestive tract morphogenesis [IMP]
- embryonic foregut morphogenesis [IMP]
- embryonic heart tube anterior/posterior pattern specification [IMP]
- embryonic heart tube development [IMP]
- embryonic morphogenesis [IMP]
- endocardial cushion development [IGI, IMP, ISO]
- endoderm formation [IMP]
- epithelial cell fate commitment [IMP]
- gastrulation with mouth forming second [IMP]
- heart development [IMP]
- heart looping [IMP]
- heart morphogenesis [IMP]
- in utero embryonic development [IMP]
- intestinal epithelial cell differentiation [ISO]
- lung lobe formation [IMP]
- lung morphogenesis [TAS]
- male gonad development [ISO]
- mitral valve formation [TAS]
- negative regulation of autophagy [ISO]
- outflow tract morphogenesis [TAS]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of angiogenesis [IDA]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation vascular endothelial growth factor production [IDA]
- regulation of cardiac muscle cell contraction [ISO]
- regulation of cardiac muscle cell proliferation [IMP]
- regulation of gene expression [IDA, IGI]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA, ISO, TAS]
- response to drug [ISO]
- response to estrogen [IDA]
- response to mechanical stimulus [ISO]
- response to retinoic acid [IDA]
- seminiferous tubule development [IMP]
- signal transduction involved in regulation of gene expression [IDA]
- skeletal muscle cell differentiation [NAS]
- spermatogenesis [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
- transdifferentiation [ISO]
- tricuspid valve formation [TAS]
- tube morphogenesis [IGI]
- vasculogenesis involved in coronary vascular morphogenesis [TAS]
- ventricular cardiac muscle tissue development [IGI]
- ventricular septum development [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- NFAT protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IDA, ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- co-SMAD binding [ISO]
- enhancer sequence-specific DNA binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA, ISO]
- NFAT protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IDA, ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- co-SMAD binding [ISO]
- enhancer sequence-specific DNA binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
PTK2
FAK, FRNK, Fadk, mKIAA4203, p125FAK
PTK2 protein tyrosine kinase 2
GO Process (50)
GO Function (12)
GO Component (14)
Gene Ontology Biological Process
- JNK cascade [ISO]
- MAPK cascade [ISO]
- angiogenesis [IMP]
- blood vessel development [IMP]
- cellular chloride ion homeostasis [ISO]
- cellular component movement [TAS]
- cellular response to transforming growth factor beta stimulus [IDA]
- central nervous system neuron axonogenesis [IMP]
- endothelial cell migration [IMP]
- ephrin receptor signaling pathway [ISO]
- epidermal growth factor receptor signaling pathway [IBA]
- establishment of nucleus localization [IDA]
- extracellular matrix organization [IMP]
- growth hormone receptor signaling pathway [ISO]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO, TAS]
- microtubule cytoskeleton organization [IDA]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IBA, ISO]
- negative regulation of axonogenesis [IMP]
- negative regulation of cell migration [ISO]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of organ growth [IGI]
- negative regulation of synapse assembly [IMP]
- neuron migration [IDA, IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of glial cell proliferation [ISO]
- positive regulation of phagocytosis [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of synaptic transmission [ISO]
- positive regulation of vasodilation [ISO]
- protein autophosphorylation [IDA, IMP, ISO]
- regulation of cell adhesion [IBA]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of cell proliferation [ISO]
- regulation of cell shape [ISO]
- regulation of osteoblast differentiation [ISO]
- transforming growth factor beta receptor signaling pathway [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [ISO]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA]
- receptor binding [IBA]
- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [ISO]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA]
- receptor binding [IBA]
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- basolateral plasma membrane [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [IDA, ISO]
- intercalated disc [ISO]
- lamellipodium [IDA]
- nuclear body [ISO]
- nucleolus [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- sarcolemma [ISO]
- stress fiber [ISO]
Mus musculus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.
Vascular cell adhesion molecule-1 (VCAM-1) plays important roles in development and inflammation. Tumor necrosis factor-α (TNF-α) and focal adhesion kinase (FAK) are key regulators of inflammatory and integrin-matrix signaling, respectively. Integrin costimulatory signals modulate inflammatory gene expression, but the important control points between these pathways remain unresolved. We report that pharmacological FAK inhibition prevented TNF-α-induced VCAM-1 expression within heart vessel-associated ... [more]
J. Cell Biol. Jun. 25, 2012; 197(7);907-19 [Pubmed: 22734001]
Throughput
- Low Throughput
Additional Notes
- figure 6.
Curated By
- BioGRID