BAIT
GATA4
Gata-4
GATA binding protein 4
GO Process (66)
GO Function (17)
GO Component (3)
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- SMAD protein signal transduction [IDA]
- Sertoli cell differentiation [IMP]
- atrial septum morphogenesis [ISO]
- atrial septum primum morphogenesis [IMP]
- atrial septum secundum morphogenesis [ISO]
- atrioventricular canal development [IGI]
- atrioventricular valve formation [IGI]
- atrioventricular valve morphogenesis [IGI, TAS]
- canonical Wnt signaling pathway [IDA]
- cardiac muscle cell differentiation [IGI, IMP, NAS]
- cardiac muscle hypertrophy in response to stress [IMP]
- cardiac muscle tissue development [IGI]
- cardiac right ventricle morphogenesis [IMP]
- cardiac septum development [IGI]
- cell growth involved in cardiac muscle cell development [ISO]
- cell-cell signaling [IMP]
- cellular response to follicle-stimulating hormone stimulus [IDA]
- cellular response to gonadotropin stimulus [IDA]
- diaphragm morphogenesis [TAS]
- embryonic digestive tract morphogenesis [IMP]
- embryonic foregut morphogenesis [IMP]
- embryonic heart tube anterior/posterior pattern specification [IMP]
- embryonic heart tube development [IMP]
- embryonic morphogenesis [IMP]
- endocardial cushion development [IGI, IMP, ISO]
- endoderm formation [IMP]
- epithelial cell fate commitment [IMP]
- gastrulation with mouth forming second [IMP]
- heart development [IMP]
- heart looping [IMP]
- heart morphogenesis [IMP]
- in utero embryonic development [IMP]
- intestinal epithelial cell differentiation [ISO]
- lung lobe formation [IMP]
- lung morphogenesis [TAS]
- male gonad development [ISO]
- mitral valve formation [TAS]
- negative regulation of autophagy [ISO]
- outflow tract morphogenesis [TAS]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of angiogenesis [IDA]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation vascular endothelial growth factor production [IDA]
- regulation of cardiac muscle cell contraction [ISO]
- regulation of cardiac muscle cell proliferation [IMP]
- regulation of gene expression [IDA, IGI]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA, ISO, TAS]
- response to drug [ISO]
- response to estrogen [IDA]
- response to mechanical stimulus [ISO]
- response to retinoic acid [IDA]
- seminiferous tubule development [IMP]
- signal transduction involved in regulation of gene expression [IDA]
- skeletal muscle cell differentiation [NAS]
- spermatogenesis [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
- transdifferentiation [ISO]
- tricuspid valve formation [TAS]
- tube morphogenesis [IGI]
- vasculogenesis involved in coronary vascular morphogenesis [TAS]
- ventricular cardiac muscle tissue development [IGI]
- ventricular septum development [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- NFAT protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IDA, ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- co-SMAD binding [ISO]
- enhancer sequence-specific DNA binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA, ISO]
- NFAT protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IDA, ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- co-SMAD binding [ISO]
- enhancer sequence-specific DNA binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
PTK2
FAK, FRNK, Fadk, mKIAA4203, p125FAK
PTK2 protein tyrosine kinase 2
GO Process (50)
GO Function (12)
GO Component (14)
Gene Ontology Biological Process
- JNK cascade [ISO]
- MAPK cascade [ISO]
- angiogenesis [IMP]
- blood vessel development [IMP]
- cellular chloride ion homeostasis [ISO]
- cellular component movement [TAS]
- cellular response to transforming growth factor beta stimulus [IDA]
- central nervous system neuron axonogenesis [IMP]
- endothelial cell migration [IMP]
- ephrin receptor signaling pathway [ISO]
- epidermal growth factor receptor signaling pathway [IBA]
- establishment of nucleus localization [IDA]
- extracellular matrix organization [IMP]
- growth hormone receptor signaling pathway [ISO]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO, TAS]
- microtubule cytoskeleton organization [IDA]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IBA, ISO]
- negative regulation of axonogenesis [IMP]
- negative regulation of cell migration [ISO]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of organ growth [IGI]
- negative regulation of synapse assembly [IMP]
- neuron migration [IDA, IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of glial cell proliferation [ISO]
- positive regulation of phagocytosis [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of synaptic transmission [ISO]
- positive regulation of vasodilation [ISO]
- protein autophosphorylation [IDA, IMP, ISO]
- regulation of cell adhesion [IBA]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of cell proliferation [ISO]
- regulation of cell shape [ISO]
- regulation of osteoblast differentiation [ISO]
- transforming growth factor beta receptor signaling pathway [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [ISO]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA]
- receptor binding [IBA]
- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [ISO]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA]
- receptor binding [IBA]
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- basolateral plasma membrane [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [IDA, ISO]
- intercalated disc [ISO]
- lamellipodium [IDA]
- nuclear body [ISO]
- nucleolus [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- sarcolemma [ISO]
- stress fiber [ISO]
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.
Vascular cell adhesion molecule-1 (VCAM-1) plays important roles in development and inflammation. Tumor necrosis factor-α (TNF-α) and focal adhesion kinase (FAK) are key regulators of inflammatory and integrin-matrix signaling, respectively. Integrin costimulatory signals modulate inflammatory gene expression, but the important control points between these pathways remain unresolved. We report that pharmacological FAK inhibition prevented TNF-α-induced VCAM-1 expression within heart vessel-associated ... [more]
J. Cell Biol. Jun. 25, 2012; 197(7);907-19 [Pubmed: 22734001]
Throughput
- Low Throughput
Additional Notes
- figure 6.
Curated By
- BioGRID