DDX58
Gene Ontology Biological Process
- RIG-I signaling pathway [IMP]
- cytoplasmic pattern recognition receptor signaling pathway in response to virus [TAS]
- detection of virus [IDA]
- innate immune response [IMP, TAS]
- negative regulation of type I interferon production [TAS]
- positive regulation of defense response to virus by host [IMP]
- positive regulation of interferon-alpha production [IDA, IMP]
- positive regulation of interferon-beta production [IDA, IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IC]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of cell migration [IDA]
- regulation of type III interferon production [TAS]
- response to virus [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TSPAN6
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Tetraspanin 6 (TSPAN6) negatively regulates RIG-I-like receptors (RLRs) mediated immune signaling in a ubiquitination dependent manner.
The recognition between RIG-I-like receptors (RLRs) and viral RNA triggers an intracellular cascade of signaling to induce the expression of type I interferons (IFNs). Both positive and negative regulation on RLRs signaling pathway are important for host anti-viral immune response. Here we demonstrated that tetraspanin protein TSPAN6 inhibits RLR signaling by affecting the formation of adaptor MAVS (mitochondria antiviral signaling) ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 4.
Curated By
- BioGRID