BAIT
VHL
Vhlh
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
GO Process (20)
GO Function (6)
GO Component (13)
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [ISO]
- angiogenesis [ISO]
- blood vessel endothelial cell migration [ISO]
- extracellular matrix organization [ISO]
- negative regulation of thymocyte apoptotic process [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- neuron differentiation [IDA]
- positive regulation of transcription, DNA-templated [ISO]
- proteasomal protein catabolic process [ISO]
- protein catabolic process [ISO]
- protein heterooligomerization [IPI]
- protein transport [ISO]
- protein ubiquitination [ISO]
- regulation of apoptotic signaling pathway [ISO]
- regulation of catecholamine metabolic process [IMP]
- regulation of thymocyte apoptotic process [ISO]
- regulation of transcription, DNA-templated [IDA, ISO]
- response to ethanol [IEP]
- response to hypoxia [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
EXOSC8
CIP3, EAP2, OIP2, PCH1C, RRP43, Rrp43p, bA421P11.3, p9, RP11-421P11.3
exosome component 8
GO Process (5)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.
The human VHL tumor suppressor gene has been implicated in the inherited disorder von Hippel-Lindau disease and in sporadic renal carcinoma. The homologous rat gene encodes a 185-amino acid protein that is 88% sequence identical to the aligned 213-amino acid human VHL gene product. When expressed in COS-7 cells, both the human and the rat VHL proteins showed predominant nuclear, ... [more]
Proc. Natl. Acad. Sci. U.S.A. Jul. 03, 1995; 92(14);6459-63 [Pubmed: 7604013]
Throughput
- Low Throughput
Curated By
- BioGRID