BAIT
USP6
HRP1, TRE17, TRE2, TRESMCR, Tre-2, USP6-short
ubiquitin specific peptidase 6
GO Process (5)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RAB33B
SMC2
RAB33B, member RAS oncogene family
GO Process (12)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- GTP catabolic process [IBA, IMP]
- Rab protein signal transduction [IBA]
- intra-Golgi vesicle-mediated transport [IMP]
- intracellular protein transport [IBA]
- negative regulation of constitutive secretory pathway [IMP]
- protein targeting to Golgi [IGI, IMP]
- regulation of Golgi organization [IMP]
- regulation of autophagic vacuole assembly [IBA, ISS]
- regulation of cell growth [IMP]
- regulation of epithelial cell proliferation [IMP]
- regulation of retrograde vesicle-mediated transport, Golgi to ER [IMP]
- skeletal system morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.
It has recently been proposed that the TBC (Tre2/Bub2/Cdc16) domain functions as a GAP (GTPase-activating protein) domain for small GTPase Rab. Because of the large number of Rab proteins in mammals, however, most TBC domains have never been investigated for Rab-GAP activity. In this study we established panels of the GTP-fixed form of 60 different Rabs constructed in pGAD-C1, a ... [more]
Genes Cells Sep. 01, 2006; 11(9);1023-37 [Pubmed: 16923123]
Throughput
- Low Throughput
Curated By
- BioGRID