BAIT
NCF1
NCF1A, NOXO2, SH3PXD1A, p47phox
neutrophil cytosolic factor 1
GO Process (11)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- innate immune response [TAS]
- interaction with host [TAS]
- oxidation-reduction process [IMP]
- phagosome maturation [TAS]
- protein targeting to membrane [IDA]
- respiratory burst [TAS]
- superoxide anion generation [IMP, TAS]
- superoxide metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SRSF2
PR264, SC-35, SC35, SFRS2, SFRS2A, SRp30b
serine/arginine-rich splicing factor 2
GO Process (9)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- RNA splicing [TAS]
- gene expression [TAS]
- mRNA 3'-end processing [TAS]
- mRNA export from nucleus [TAS]
- mRNA processing [TAS]
- mRNA splicing, via spliceosome [TAS]
- negative regulation of nucleic acid-templated transcription [NAS]
- termination of RNA polymerase II transcription [TAS]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF.
Toll-like receptors (TLR) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase play an essential role in intracellular eradication of engulfed pathogens. Here, we demonstrate the physical and functional association between components of the cytosolic NADPH oxidase and TLR-mediated signaling molecules. Cytosolic components of NADPH oxidase suppressed TLR-mediated NF-kappaB activation as well as IFN-beta promoter activation. We demonstrate that TNF-associated factor (TRAF) ... [more]
Eur. J. Immunol. Aug. 01, 2005; 35(8);2477-85 [Pubmed: 16052631]
Throughput
- Low Throughput
Curated By
- BioGRID