COPS5
Gene Ontology Biological Process
- cullin deneddylation [ISO]
- exosomal secretion [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein deneddylation [ISO]
- protein deubiquitination [ISO]
- proteolysis [ISO]
- regulation of JNK cascade [ISO]
- regulation of cell cycle [IMP]
- regulation of transcription, DNA-templated [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
XPO1
Gene Ontology Biological Process
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- protein export from nucleus [IDA, IMP, ISO]
- protein localization to nucleus [IMP]
- regulation of centrosome duplication [IMP]
- regulation of protein catabolic process [IMP]
- regulation of protein export from nucleus [IMP]
- ribosomal large subunit export from nucleus [ISO]
- ribosomal small subunit export from nucleus [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex.
The fifth component of the COP9 signalosome complex, Jab1/CSN5, directly binds to and induces specific down-regulation of the cyclin-dependent kinase inhibitor p27 (p27(Kip1)). Nuclear-cytoplasmic translocation plays an important role because leptomycin B (LMB), a chemical inhibitor of CRM1-dependent nuclear export, prevents p27 degradation mediated by Jab1/CSN5. Here we show that Jab1/CSN5 functions as an adaptor between p27 and CRM1 to ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID