GNAI1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISS]
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IBA]
- blood coagulation [TAS]
- cell division [IMP]
- platelet activation [TAS]
- response to peptide hormone [ISS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PTH1R
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [ISS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IDA]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IC]
- positive regulation of inositol phosphate biosynthetic process [ISS]
- skeletal system development [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A docking site for G protein βγ subunits on the parathyroid hormone 1 receptor supports signaling through multiple pathways.
The G protein-coupled receptor for PTH and PTH-related protein (PTH1R) signals via many intracellular pathways. The purpose of this work is to investigate a G protein binding site on an intracellular domain of the PTH1R. The carboxy-terminal, cytoplasmic tail of the PTH1R fused to glutathione-S-transferase interacts with Gi/o proteins in vitro. All three subunits of the heterotrimer interact with the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID