SELPLG
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TNIP1
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [ISS]
- defense response [TAS]
- glycoprotein biosynthetic process [IDA]
- leukocyte cell-cell adhesion [IMP]
- modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of viral genome replication [TAS]
- positive regulation of inflammatory response [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- translation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
P-selectin primes leukocyte integrin activation during inflammation.
Selectins mediate leukocyte rolling and prime leukocytes for integrin-mediated leukocyte adhesion. However, neither the in vivo importance of nor the signaling pathway by which selectin-mediated integrin activation occurs has been determined. We report here that P-selectin-deficient mice manifested impaired leukocyte adhesion, which was 'rescued' by soluble P-selectin. Mechanistically, the cytoplasmic domain of P-selectin glycoprotein ligand 1 formed a constitutive complex ... [more]
Throughput
- Low Throughput
Additional Notes
- figure S2.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TNIP1 SELPLG | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 697461 | |
| SELPLG TNIP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 697462 |
Curated By
- BioGRID