ITPK1
Gene Ontology Biological Process
Gene Ontology Molecular Function- catalytic activity [TAS]
- inositol tetrakisphosphate 1-kinase activity [TAS]
- inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity [TAS]
- inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity [TAS]
- inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity [TAS]
- inositol-1,3,4-trisphosphate 5-kinase activity [TAS]
- inositol-1,3,4-trisphosphate 6-kinase activity [TAS]
- inositol-3,4,6-trisphosphate 1-kinase activity [TAS]
- catalytic activity [TAS]
- inositol tetrakisphosphate 1-kinase activity [TAS]
- inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity [TAS]
- inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity [TAS]
- inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity [TAS]
- inositol-1,3,4-trisphosphate 5-kinase activity [TAS]
- inositol-1,3,4-trisphosphate 6-kinase activity [TAS]
- inositol-3,4,6-trisphosphate 1-kinase activity [TAS]
NFKBIA
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- apoptotic process [TAS]
- cellular response to cold [NAS]
- cytoplasmic sequestering of NF-kappaB [IMP]
- cytoplasmic sequestering of transcription factor [IDA]
- innate immune response [TAS]
- negative regulation of DNA binding [NAS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of apoptotic process [TAS]
- negative regulation of lipid storage [IMP]
- negative regulation of macrophage derived foam cell differentiation [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of cholesterol efflux [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of type I interferon production [TAS]
- regulation of NF-kappaB import into nucleus [NAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1.
The COP9 signalosome (CSN) is a complex of eight proteins first identified as a repressor of plant photomorphogenesis. A protein kinase activity associated with the COP9 signalosome has been reported but not identified; we present evidence for inositol 1,3,4-trisphosphate 5/6-kinase (5/6-kinase) as a protein kinase associated with the COP9 signalosome. We have shown that 5/6-kinase exists in a complex with ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID