AIFM1
Gene Ontology Biological Process
- DNA catabolic process [TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- apoptotic DNA fragmentation [TAS]
- apoptotic process [IMP]
- chromosome condensation [TAS]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- mitochondrial respiratory chain complex I assembly [IMP]
- neuron differentiation [IDA]
- positive regulation of apoptotic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BAG6
Gene Ontology Biological Process
- brain development [ISS]
- embryo development [ISS]
- internal peptidyl-lysine acetylation [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- kidney development [ISS]
- lung development [ISS]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- negative regulation of proteolysis [ISS]
- protein stabilization [ISS]
- spermatogenesis [ISS]
- synaptonemal complex assembly [ISS]
- tail-anchored membrane protein insertion into ER membrane [IDA]
- ubiquitin-dependent protein catabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis.
Scythe (BAT3; HLA-B associated transcript 3, Bag 6) is a protein that has been implicated in apoptosis because it can modulate the Drosophila melanogaster apoptotic regulator, Reaper. Mice lacking Scythe show pronounced defects in organogenesis and in the regulation of apoptosis and proliferation during mammalian development. However, the biochemical pathways important for Scythe function are unknown. We report here multiple ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BAG6 AIFM1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| AIFM1 BAG6 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID