BAIT
FASLG
ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6
Fas ligand (TNF superfamily, member 6)
GO Process (16)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- T cell apoptotic process [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IGI, IMP, TAS]
- apoptotic process [TAS]
- apoptotic signaling pathway [IDA, TAS]
- cell-cell signaling [TAS]
- extrinsic apoptotic signaling pathway [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- necroptotic process [IDA]
- necroptotic signaling pathway [IDA]
- negative regulation of angiogenesis [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of apoptotic process [IDA]
- positive regulation of endothelial cell apoptotic process [IDA]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NCKIPSD
AF3P21, DIP, DIP1, ORF1, SPIN90, VIP54, WASLBP, WISH
NCK interacting protein with SH3 domain
GO Process (5)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
Fas ligand is a cytotoxic effector molecule of T and NK cells which is characterized by an intracellular N-terminal polyproline region that serves as a docking site for SH3 and WW domain proteins. Several previously described Fas ligand-interacting SH3 domain proteins turned out to be crucial for the regulation of storage, expression and function of the death factor. Recent observations, ... [more]
BMC Immunol. Oct. 08, 2009; 10(0);53 [Pubmed: 19807924]
Throughput
- Low Throughput
Curated By
- BioGRID