FASLG
Gene Ontology Biological Process
- T cell apoptotic process [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IGI, IMP, TAS]
- apoptotic process [TAS]
- apoptotic signaling pathway [IDA, TAS]
- cell-cell signaling [TAS]
- extrinsic apoptotic signaling pathway [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- necroptotic process [IDA]
- necroptotic signaling pathway [IDA]
- negative regulation of angiogenesis [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of apoptotic process [IDA]
- positive regulation of endothelial cell apoptotic process [IDA]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ITK
Gene Ontology Biological Process
- B cell receptor signaling pathway [IBA]
- Fc-epsilon receptor signaling pathway [TAS]
- NK T cell differentiation [IBA]
- T cell activation [TAS]
- T cell receptor signaling pathway [IBA, ISS, TAS]
- activation of phospholipase C activity [ISS]
- adaptive immune response [IBA, ISS]
- cellular defense response [TAS]
- cytokine production [ISS]
- innate immune response [IBA, TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- regulation of cell proliferation [IBA]
- signal transduction [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
Fas ligand is a cytotoxic effector molecule of T and NK cells which is characterized by an intracellular N-terminal polyproline region that serves as a docking site for SH3 and WW domain proteins. Several previously described Fas ligand-interacting SH3 domain proteins turned out to be crucial for the regulation of storage, expression and function of the death factor. Recent observations, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FASLG ITK | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID