CASP8
Gene Ontology Biological Process
- TRAIL-activated apoptotic signaling pathway [ISO]
- activation of cysteine-type endopeptidase activity [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- angiogenesis [IMP]
- apoptotic process [IDA, ISO]
- apoptotic signaling pathway [IDA, ISO]
- cardiac muscle tissue development [TAS]
- execution phase of apoptosis [ISO]
- extrinsic apoptotic signaling pathway [IDA, IGI, ISO]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- heart development [IMP]
- hepatocyte apoptotic process [IMP]
- macrophage differentiation [IMP, TAS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of necroptotic process [IGI]
- neural tube formation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IGI]
- positive regulation of macrophage differentiation [ISO]
- positive regulation of proteolysis [ISO]
- protein heterooligomerization [ISO]
- proteolysis [IGI, ISO]
- proteolysis involved in cellular protein catabolic process [ISO]
- regulation of apoptotic signaling pathway [IGI]
- regulation of thymocyte apoptotic process [IGI]
- response to ethanol [ISO]
- response to tumor necrosis factor [ISO]
Gene Ontology Molecular Function- cysteine-type endopeptidase activity [IDA, IGI, ISO]
- cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISO]
- death effector domain binding [IBA, ISO]
- death receptor binding [ISO]
- endopeptidase activity [IDA, IMP]
- peptidase activity [IDA, IMP, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [IPI]
- scaffold protein binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- cysteine-type endopeptidase activity [IDA, IGI, ISO]
- cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISO]
- death effector domain binding [IBA, ISO]
- death receptor binding [ISO]
- endopeptidase activity [IDA, IMP]
- peptidase activity [IDA, IMP, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [IPI]
- scaffold protein binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- CD95 death-inducing signaling complex [ISO]
- Noc1p-Noc2p complex [IMP]
- cell body [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- death-inducing signaling complex [ISO]
- membrane raft [ISO]
- microtubule organizing center [ISO]
- mitochondrion [IDA, ISO]
- neuron projection [ISO]
- nucleoplasm [ISO]
- nucleus [IDA]
- protein complex [ISO]
- ripoptosome [ISO]
CYLD
Gene Ontology Biological Process
- necroptotic process [IGI]
- negative regulation of NF-kappaB import into nucleus [ISO]
- negative regulation of NF-kappaB transcription factor activity [IBA, ISO]
- negative regulation of T cell differentiation [IDA]
- negative regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IBA, ISO]
- protein K63-linked deubiquitination [IBA, ISO]
- protein deubiquitination [IMP]
- proteolysis [IBA]
- regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- regulation of microtubule cytoskeleton organization [ISO]
- regulation of mitotic cell cycle [IBA, ISO]
- ripoptosome assembly involved in necroptotic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Proteolytic Processing)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Caspase 8 inhibits programmed necrosis by processing CYLD.
Caspase 8 initiates apoptosis downstream of TNF death receptors by undergoing autocleavage and processing the executioner caspase 3 (ref. 1). However, the dominant function of caspase 8 is to transmit a pro-survival signal that suppresses programmed necrosis (or necroptosis) mediated by RIPK1 and RIPK3 (refs 2-6) during embryogenesis and haematopoiesis(7-9). Suppression of necrotic cell death by caspase 8 requires its ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID