F2RL1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- T cell activation involved in immune response [ISS]
- chemokine (C-C motif) ligand 2 secretion [IDA]
- chemokine secretion [IDA]
- defense response to virus [IDA]
- establishment of endothelial barrier [IDA]
- interferon-gamma secretion [ISS]
- interleukin-1 beta secretion [IDA]
- interleukin-10 secretion [IDA]
- leukocyte migration [IDA]
- leukocyte proliferation [ISS]
- mature conventional dendritic cell differentiation [IDA, ISS]
- negative regulation of JNK cascade [IDA]
- negative regulation of chemokine secretion [IDA]
- negative regulation of toll-like receptor 3 signaling pathway [IMP]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- neutrophil activation [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of Rho protein signal transduction [IMP, ISS]
- positive regulation of actin filament depolymerization [IDA]
- positive regulation of cell migration [ISS]
- positive regulation of chemotaxis [ISS]
- positive regulation of cytokine secretion involved in immune response [IDA]
- positive regulation of cytosolic calcium ion concentration [IDA, ISS]
- positive regulation of eosinophil degranulation [IDA]
- positive regulation of glomerular filtration [ISS]
- positive regulation of interleukin-6 secretion [IDA]
- positive regulation of interleukin-8 secretion [IDA]
- positive regulation of leukocyte chemotaxis [IDA]
- positive regulation of neutrophil mediated killing of gram-negative bacterium [IDA]
- positive regulation of phagocytosis, engulfment [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of positive chemotaxis [IDA]
- positive regulation of pseudopodium assembly [ISS]
- positive regulation of renin secretion into blood stream [ISS]
- positive regulation of superoxide anion generation [IDA]
- positive regulation of toll-like receptor 2 signaling pathway [IMP]
- positive regulation of toll-like receptor 3 signaling pathway [IMP]
- positive regulation of toll-like receptor 4 signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of vasodilation [ISS]
- regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- regulation of JNK cascade [IDA]
- regulation of blood coagulation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
COPS5
Gene Ontology Biological Process
- cullin deneddylation [IDA]
- exosomal secretion [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein deneddylation [IMP]
- protein deubiquitination [IDA]
- regulation of JNK cascade [IDA]
- transcription from RNA polymerase II promoter [TAS]
- translation [TAS]
- translational initiation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1.
Protease-activated receptor-2 (PAR-2), a G protein-coupled receptor for trypsin and tryptase, exerts important physiological and pathological functions in multiple systems. However, unlike PAR-1, the PAR-2-mediated intracellular signal transductions are hardly known. Here, using yeast two-hybrid screening with a human brain cDNA library, we identified an interacting partner of human PAR-2, the Jun activation domain-binding protein 1 (Jab1). The interaction was ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| F2RL1 COPS5 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| F2RL1 COPS5 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID