KAR2
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IMP]
- SRP-dependent cotranslational protein targeting to membrane, translocation [IMP]
- karyogamy involved in conjugation with cellular fusion [IGI, IMP]
- posttranslational protein targeting to membrane, translocation [IDA, IMP]
- response to unfolded protein [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SEC2
Gene Ontology Biological Process
- autophagy [IGI, IMP]
- exocytosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Coiled-Coil Networking Shapes Cell Molecular Machinery.
The highly abundant alpha-helical coiled-coil motif not only mediates crucial protein-protein interactions in the cell, but is also an attractive scaffold in synthetic biology and material science and a potential target for disease intervention. Therefore, a systematic understanding of the coiled-coil interactions at the organismal level would help unravel the full spectrum of the biological function of this interaction motif ... [more]
Throughput
- High Throughput
Additional Notes
- Interaction between cloned coiled-coil domains
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SEC2 KAR2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.13 | BioGRID | 1950223 |
Curated By
- BioGRID