GNB1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP, ISO, TAS]
- GTP catabolic process [ISO]
- cardiac muscle cell apoptotic process [IDA]
- cell proliferation [ISO]
- cellular response to hypoxia [IDA]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISO]
- positive regulation of cytosolic calcium ion concentration [IMP]
- retina development in camera-type eye [ISO]
- sensory perception of taste [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CACNA1A
Gene Ontology Biological Process
- adult walking behavior [ISO]
- behavioral response to pain [ISO]
- calcium ion import [IDA, IMP]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [IDA, IMP, ISO]
- calcium ion-dependent exocytosis [ISO]
- calcium ion-dependent exocytosis of neurotransmitter [ISO]
- cell death [ISO]
- cell growth [ISO]
- cellular chloride ion homeostasis [ISO]
- central nervous system neuron differentiation [ISO]
- cerebellar Purkinje cell differentiation [ISO]
- cerebellar Purkinje cell layer development [ISO]
- cerebellar molecular layer development [ISO]
- cerebellum maturation [ISO]
- dendrite morphogenesis [ISO]
- gamma-aminobutyric acid secretion [ISO]
- gamma-aminobutyric acid signaling pathway [ISO]
- glucose metabolic process [ISO]
- hormone metabolic process [ISO]
- membrane depolarization [ISO]
- membrane depolarization during action potential [IBA]
- musculoskeletal movement, spinal reflex action [ISO]
- negative regulation of hormone biosynthetic process [ISO]
- negative regulation of neuron apoptotic process [ISO]
- neurological system process [ISO]
- neuromuscular process [ISO]
- neuromuscular process controlling balance [ISO]
- neuromuscular synaptic transmission [ISO]
- neuron-neuron synaptic transmission [ISO]
- neurotransmitter metabolic process [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO, ISS]
- receptor clustering [ISO]
- regulation of acetylcholine secretion, neurotransmission [ISO]
- regulation of axonogenesis [ISO]
- regulation of calcium ion-dependent exocytosis [ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of membrane potential [ISO]
- response to pain [ISO]
- rhythmic synaptic transmission [ISO]
- sensory perception of pain [IMP]
- spinal cord motor neuron differentiation [ISO]
- sulfur amino acid metabolic process [ISO]
- synapse assembly [ISO]
- synaptic transmission [IMP, ISO]
- synaptic transmission, GABAergic [ISO]
- synaptic transmission, glutamatergic [ISO]
- thyroid hormone metabolic process [ISO]
- transmission of nerve impulse [ISO]
- vestibular nucleus development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.
Voltage-dependent G protein (Gbetagamma) inhibition of N-type (CaV2.2) channels supports presynaptic inhibition and represents a central paradigm of channel modulation. Still controversial are the proposed determinants for such modulation, which reside on the principal alpha1B channel subunit. These include the interdomain I-II loop (I-II), the carboxy tail (CT), and the amino terminus (NT). Here, we probed these determinants and related ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GNB1 CACNA1A | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID