BAIT
CHMP4A
C14orf123, CHMP4, CHMP4B, HSPC134, SHAX2, SNF7, SNF7-1, VPS32-1, VPS32A, CDA04
charged multivesicular body protein 4A
GO Process (11)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- endosomal transport [TAS]
- membrane budding [IGI, IMP]
- membrane organization [TAS]
- membrane tubulation [IGI, IMP]
- negative regulation of autophagic vacuole assembly [IMP]
- negative regulation of neuron death [IMP]
- posttranslational protein targeting to membrane [IMP]
- protein homooligomerization [IMP]
- viral budding via host ESCRT complex [IGI]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CC2D1A
FREUD-1, Freud-1/Aki1, MRT3
coiled-coil and C2 domain containing 1A
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.
In Saccharomyces cerevisiae 6 closely related proteins (Did2p, Vps2p, Vps24p, Vps32p, Vps60p, Vps20p) form part of the extended ESCRT III complex. This complex is required for the formation of multivesicular bodies and the degradation of internalized transmembrane receptor proteins. In contrast the human genome encodes 10 homologous proteins (CHMP1A (approved gene symbol PCOLN3), 1B, 2A, 2B, 3 (approved gene symbol ... [more]
Genomics Sep. 01, 2006; 88(3);333-46 [Pubmed: 16730941]
Throughput
- High Throughput
Additional Notes
- table 1.
Curated By
- BioGRID