Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures.

Suzuki A, Yamanaka T, Hirose T, Manabe N, Mizuno K, Shimizu M, Akimoto K, Izumi Y, Ohnishi T, Ohno S

We have previously shown that during early Caenorhabditis elegans embryogenesis PKC-3, a C. elegans atypical PKC (aPKC), plays critical roles in the establishment of cell polarity required for subsequent asymmetric cleavage by interacting with PAR-3 [Tabuse, Y., Y. Izumi, F. Piano, K.J. Kemphues, J. Miwa, and S. Ohno. 1998. Development (Camb.). 125:3607--3614]. Together with the fact that aPKC and a ... [more]

J. Cell Biol. Mar. 19, 2001; 152(6);1183-96 [Pubmed: 11257119]

Throughput

Low Throughput

Additional Notes

figure 9.

Curated By

BioGRID

Interaction Summary

PARD6A

Gene Ontology Biological Process

Gene Ontology Molecular Function

GTP-dependent protein binding [ISS]Rho GTPase binding [ISS]protein binding [IPI]transcription factor binding [TAS]

Gene Ontology Cellular Component

TJP1