NUMB
Gene Ontology Biological Process
- adherens junction organization [IGI]
- axonogenesis [IDA, IMP]
- forebrain development [IMP]
- lateral ventricle development [IMP]
- lung epithelial cell differentiation [IMP]
- negative regulation of Notch signaling pathway [IMP]
- negative regulation of protein localization to plasma membrane [ISO]
- nervous system development [IMP]
- neuroblast division in subventricular zone [IMP]
- neuroblast proliferation [IGI]
- positive regulation of cell migration [ISO]
- positive regulation of dendrite morphogenesis [ISO]
- positive regulation of neurogenesis [IMP]
- positive regulation of polarized epithelial cell differentiation [IMP]
- regulation of neuron differentiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
LNX1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Far Western
An interaction is detected between a protein immobilized on a membrane and a purified protein probe.
Publication
The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX.
Numb is a phosphotyrosine-binding (PTB) domain-containing protein implicated in the control of cell fate decisions during development. A modified two-hybrid screen in yeast was used to identify Numb PTB domain-interacting proteins important for Numb function. Here we report the identification of a novel protein, LNX, which interacts specifically with the Numb PTB domain. Two differentially expressed LNX messages encode overlapping ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NUMB LNX1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID