BAIT
MYOC
GLC1A, GPOA, JOAG, JOAG1, TIGR, myocilin
myocilin, trabecular meshwork inducible glucocorticoid response
GO Process (19)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- ERBB2-ERBB3 signaling pathway [ISS]
- bone development [ISS]
- clustering of voltage-gated sodium channels [ISS]
- myelination in peripheral nervous system [ISS]
- negative regulation of Rho protein signal transduction [IDA]
- negative regulation of cell-matrix adhesion [IDA]
- negative regulation of stress fiber assembly [IDA]
- neuron projection development [IMP]
- non-canonical Wnt signaling pathway via JNK cascade [IMP]
- osteoblast differentiation [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of focal adhesion assembly [IDA]
- positive regulation of mitochondrial depolarization [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of stress fiber assembly [IDA]
- positive regulation of substrate adhesion-dependent cell spreading [IDA]
- regulation of MAPK cascade [IDA]
- skeletal muscle hypertrophy [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GAPDH
G3PD, GAPD, HEL-S-162eP, CDABP0047
glyceraldehyde-3-phosphate dehydrogenase
GO Process (11)
GO Function (5)
GO Component (13)
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cellular response to interferon-gamma [IDA]
- gluconeogenesis [TAS]
- glucose metabolic process [TAS]
- glycolytic process [TAS]
- microtubule cytoskeleton organization [ISS]
- negative regulation of translation [IDA, IMP]
- neuron apoptotic process [ISS]
- peptidyl-cysteine S-trans-nitrosylation [ISS]
- protein stabilization [ISS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- GAIT complex [IDA]
- cytoplasm [IDA, ISS]
- cytosol [IDA, ISS, TAS]
- extracellular vesicular exosome [IDA]
- intracellular membrane-bounded organelle [IDA]
- lipid particle [IDA]
- membrane [IDA]
- microtubule cytoskeleton [ISS]
- nuclear membrane [IDA]
- nucleus [IDA, ISS]
- plasma membrane [IDA]
- ribonucleoprotein complex [IDA]
- vesicle [IDA]
Homo sapiens
Far Western
An interaction is detected between a protein immobilized on a membrane and a purified protein probe.
Publication
The identification of myocilin-associated proteins in the human trabecular meshwork.
Myocilin forms high molecular weight complexes in vivo presumably due to interaction with itself and other myocilin binding proteins. To identify myocilin interacting proteins, yeast 2-hybrid analysis was performed on >1x10(6) human trabecular meshwork cDNA clones. Coimmunoprecipitation and Far Western analysis were also performed on cell lysates obtained from fresh human trabecular meshworks or cultured human monolayer trabecular cell lines. ... [more]
Exp. Eye Res. Jun. 01, 2006; 82(6);1046-52 [Pubmed: 16289162]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MYOC GAPDH | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID