BAIT
PAX6
1500038E17Rik, AEY11, Dey, Gsfaey11, Pax-6, Sey, RP23-431C3.1
paired box 6
GO Process (75)
GO Function (21)
GO Component (7)
Gene Ontology Biological Process
- anterior/posterior pattern specification [IGI, IMP]
- astrocyte differentiation [IMP, ISO]
- axon guidance [IMP]
- axonogenesis [IMP]
- blood vessel development [ISO]
- brain development [IMP, ISO]
- camera-type eye development [IGI, IMP]
- cell differentiation [IMP]
- cell fate commitment [IGI, IMP]
- cell fate determination [IMP]
- cerebral cortex regionalization [IMP]
- commitment of neuronal cell to specific neuron type in forebrain [IMP]
- cornea development in camera-type eye [ISO]
- dorsal/ventral axis specification [IMP]
- dorsal/ventral pattern formation [IMP]
- embryonic camera-type eye morphogenesis [IGI]
- epithelial cell development [ISO]
- establishment of mitotic spindle orientation [IMP]
- eye photoreceptor cell development [IMP]
- forebrain anterior/posterior pattern specification [IMP]
- forebrain development [IMP]
- forebrain dorsal/ventral pattern formation [IMP]
- forebrain-midbrain boundary formation [IMP]
- glucose homeostasis [ISO]
- hindbrain development [ISO]
- insulin metabolic process [ISO]
- interkinetic nuclear migration [ISO]
- iris morphogenesis [ISO]
- keratinocyte differentiation [IMP]
- lacrimal gland development [IMP]
- lens development in camera-type eye [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of neural precursor cell proliferation [IMP]
- negative regulation of neuron differentiation [IGI]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- neural crest cell migration [ISO]
- neural precursor cell proliferation [ISO]
- neuron migration [IMP, ISO]
- olfactory bulb development [ISO]
- oligodendrocyte cell fate specification [IMP]
- pallium development [IMP]
- pancreatic A cell development [IMP, ISO]
- pancreatic A cell differentiation [ISO]
- pituitary gland development [IMP]
- positive regulation of cell fate specification [ISO]
- positive regulation of epithelial cell differentiation [IMP]
- positive regulation of gene expression [IMP, ISO]
- positive regulation of glucagon secretion [ISO]
- positive regulation of neuroblast proliferation [IMP]
- positive regulation of neuron migration [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- protein localization to organelle [IMP]
- regulation of asymmetric cell division [IMP]
- regulation of cell migration [IMP]
- regulation of gene expression [IMP]
- regulation of neurogenesis [IMP, ISO]
- regulation of neuron differentiation [ISO]
- regulation of neuron projection development [ISO]
- regulation of timing of cell differentiation [IMP]
- regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment [IMP]
- regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification [IMP]
- regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification [IMP]
- regulation of transcription, DNA-templated [TAS]
- retina development in camera-type eye [IGI]
- rhombomere morphogenesis [ISO]
- salivary gland morphogenesis [IMP]
- signal transduction involved in regulation of gene expression [IDA]
- smoothened signaling pathway [IDA]
- telencephalon regionalization [IMP]
- transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- type B pancreatic cell differentiation [IMP, ISO]
Gene Ontology Molecular Function- AT DNA binding [ISO]
- DNA binding [IDA]
- HMG box domain binding [IPI]
- R-SMAD binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA]
- co-SMAD binding [IDA]
- double-stranded DNA binding [ISO]
- histone acetyltransferase binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
- AT DNA binding [ISO]
- DNA binding [IDA]
- HMG box domain binding [IPI]
- R-SMAD binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA]
- co-SMAD binding [IDA]
- double-stranded DNA binding [ISO]
- histone acetyltransferase binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Mus musculus
PREY
DYNLL1
DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, PIN, hdlc1
dynein, light chain, LC8-type 1
GO Process (11)
GO Function (1)
GO Component (11)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- actin cytoskeleton organization [TAS]
- anatomical structure morphogenesis [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- apoptotic process [TAS]
- female gamete generation [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic cell cycle [TAS]
- negative regulation of phosphorylation [IDA]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11.
The PAX6 protein is a transcriptional regulator with a key role in ocular and neurological development. Individuals with heterozygous loss-of-function mutations in the PAX6 gene have malformations of the eye and brain. Little is known about the interactions of PAX6 with other proteins, so we carried out a systematic screen for proteins that interact with PAX6.We used bioinformatics techniques to ... [more]
BMC Genet. Aug. 16, 2005; 6(0);43 [Pubmed: 16098226]
Throughput
- Low Throughput
Curated By
- BioGRID