An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1.

Goettel JA, Liang D, Hilliard VC, Edelblum KL, Broadus MR, Gould KL, Hanks SK, Polk DB

The extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway is a highly conserved signaling pathway that regulates diverse cellular processes including differentiation, proliferation, and survival. Kinase suppressor of Ras-1 (KSR1) binds each of the three ERK cascade components to facilitate pathway activation. Even though KSR1 contains a C-terminal kinase domain, evidence supporting the catalytic function of KSR1 remains controversial. In this ... [more]

Exp. Cell Res. Feb. 15, 2011; 317(4);452-63 [Pubmed: 21144847]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

KSR1

Gene Ontology Biological Process

Gene Ontology Molecular Function

MAP-kinase scaffold activity [IDA]mitogen-activated protein kinase kinase binding [ISO]protein C-terminus binding [ISO]protein binding [IPI]

Gene Ontology Cellular Component

MBP