SLC6A3
Gene Ontology Biological Process
- adenohypophysis development [IMP]
- cation transmembrane transport [IMP, ISO]
- dopamine biosynthetic process [IMP]
- dopamine catabolic process [IMP]
- dopamine transport [IMP, ISO]
- lactation [IMP]
- locomotory behavior [IGI, IMP]
- monoamine transport [ISO]
- neurotransmitter transport [ISO]
- positive regulation of multicellular organism growth [IMP]
- prepulse inhibition [IMP]
- regulation of dopamine metabolic process [IMP]
- response to cAMP [ISO]
- response to cocaine [IDA]
- response to ethanol [ISO]
- sensory perception of smell [IMP]
- sodium ion transmembrane transport [ISO]
Gene Ontology Molecular Function- dopamine binding [IDA]
- dopamine transmembrane transporter activity [IMP, ISO]
- dopamine:sodium symporter activity [ISO]
- drug binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- protease binding [ISO]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase 2A binding [ISO]
- receptor binding [ISO]
- dopamine binding [IDA]
- dopamine transmembrane transporter activity [IMP, ISO]
- dopamine:sodium symporter activity [ISO]
- drug binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- protease binding [ISO]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase 2A binding [ISO]
- receptor binding [ISO]
Gene Ontology Cellular Component
STX1A
Gene Ontology Biological Process
- calcium ion-dependent exocytosis [IMP]
- intracellular protein transport [IBA]
- positive regulation of exocytosis [ISO]
- positive regulation of neurotransmitter secretion [ISO]
- regulation of exocytosis [ISO]
- response to gravity [ISO]
- secretion by cell [ISO]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- vesicle docking [IBA]
Gene Ontology Molecular Function- ATP-dependent protein binding [ISO]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, ISO]
- calcium channel inhibitor activity [IMP]
- calcium-dependent protein binding [ISO]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [ISO]
- kinase binding [ISO]
- myosin binding [IBA, ISO]
- myosin head/neck binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- ATP-dependent protein binding [ISO]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, ISO]
- calcium channel inhibitor activity [IMP]
- calcium-dependent protein binding [ISO]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [ISO]
- kinase binding [ISO]
- myosin binding [IBA, ISO]
- myosin head/neck binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
Gene Ontology Cellular Component
- SNARE complex [ISO]
- actomyosin [ISO]
- cell [IMP]
- endomembrane system [IBA]
- integral component of membrane [IBA]
- intracellular [IBA]
- intracellular organelle [ISO]
- membrane [IDA]
- neuron projection [IDA, ISO]
- plasma membrane [IDA, ISO, TAS]
- protein complex [ISO]
- secretory granule [ISO]
- synaptic vesicle [IDA]
- synaptic vesicle membrane [IDA]
- synaptobrevin 2-SNAP-25-syntaxin-1a complex [IDA, ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux.
The soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein syntaxin 1A (SYN1A) interacts with and regulates the function of transmembrane proteins, including ion channels and neurotransmitter transporters. Here, we define the first 33 amino acids of the N terminus of the dopamine (DA) transporter (DAT) as the site of direct interaction with SYN1A. Amphetamine (AMPH) increases the association of SYN1A with ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID