BAIT
RABGEF1
Rab5ef, Rabex5, Rin2
RAB guanine nucleotide exchange factor (GEF) 1
GO Process (13)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- negative regulation of Kit signaling pathway [IMP]
- negative regulation of Ras protein signal transduction [IMP]
- negative regulation of inflammatory response [IMP]
- negative regulation of interleukin-6 secretion [IMP]
- negative regulation of leukocyte migration [IMP]
- negative regulation of mast cell activation [IMP]
- negative regulation of mast cell degranulation [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of receptor-mediated endocytosis [IMP]
- positive regulation of Rab GTPase activity [ISO]
- protein targeting to membrane [ISO]
- protein ubiquitination [IDA]
- regulation of Fc receptor mediated stimulatory signaling pathway [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RABEP1
Rab5ep, rabaptin-5, rabaptin-5alpha, DN-279H6.1
rabaptin, RAB GTPase binding effector protein 1
GO Process (0)
GO Function (2)
GO Component (3)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion.
Using the yeast two-hybrid system, we have identified a novel 62 kDa coiled-coil protein that specifically interacts with the GTP-bound form of Rab5, a small GTPase that regulates membrane traffic in the early endocytic pathway. This protein shares 42% sequence identity with Rabaptin-5, a previously identified effector of Rab5, and we therefore named it Rabaptin-5beta. Like Rabaptin-5, Rabaptin-5beta displays heptad ... [more]
EMBO J. Apr. 01, 1998; 17(7);1930-40 [Pubmed: 9524116]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
RABGEF1 RABEP1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID