CBLB
Gene Ontology Biological Process
- T cell activation [IMP]
- immune response [IMP]
- intracellular signal transduction [IMP]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of alpha-beta T cell proliferation [IMP]
- positive regulation of T cell anergy [IMP]
- positive regulation of protein catabolic process [IMP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SORBS1
Gene Ontology Biological Process
- cellular response to insulin stimulus [IC, IMP]
- focal adhesion assembly [IDA]
- glucose transport [IDA]
- insulin receptor signaling pathway [IC, IDA]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- positive regulation of glucose import [IMP]
- positive regulation of glycogen biosynthetic process [IMP]
- positive regulation of lipid biosynthetic process [IMP]
- positive regulation of signal transduction [IPI]
- stress fiber assembly [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell-cell adherens junction [IDA]
- cell-substrate adherens junction [IDA]
- centrosome [ISO]
- cytoplasm [ISO]
- cytoskeleton [IDA]
- cytosol [IDA]
- flotillin complex [IC]
- focal adhesion [ISO]
- insulin receptor complex [ISO]
- membrane [IDA]
- membrane raft [IDA]
- nuclear matrix [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- stress fiber [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport.
Previous studies suggest that the stimulation of glucose transport by insulin involves the tyrosine phosphorylation of c-Cbl and the translocation of the c-Cbl/CAP complex to lipid raft subdomains of the plasma membrane. We now demonstrate that Cbl-b also undergoes tyrosine phosphorylation and membrane translocation in response to insulin in 3T3-L1 adipocytes. Ectopic expression of APS facilitated insulin-stimulated phosphorylation of tyrosines ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID