BAIT

ATXN10

E46L, HUMEEP, SCA10, RP1-37M3.7
ataxin 10
GO Process (2)
GO Function (1)
GO Component (7)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

GOLGA1

golgin-97, RP11-175D17.2
golgin A1
GO Process (0)
GO Function (0)
GO Component (2)

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit.

Waragai M, Nagamitsu S, Xu W, Li YJ, Lin X, Ashizawa T

Spinocerebellar ataxia type 10 (SCA10) is a dominantly inherited disorder caused by an intronic ATTCT pentanucleotide repeat expansion. The ATXN10 gene encodes a novel protein, ataxin 10, known previously as E46L, which is widely expressed in the brain. Ataxin 10 deficiency has been shown recently to cause increased apoptosis in primary cerebellar cultures, thus implicated in SCA10 pathogenesis. The biologic ... [more]

J. Neurosci. Res. May. 15, 2006; 83(7);1170-8 [Pubmed: 16498633]

Throughput

  • Low Throughput

Curated By

  • BioGRID