KCNA5
Gene Ontology Biological Process
- atrial cardiac muscle cell action potential [IMP]
- membrane hyperpolarization [IMP]
- potassium ion export [IDA, IMP]
- potassium ion transport [IDA]
- regulation of atrial cardiac muscle cell membrane repolarization [IMP]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of insulin secretion [TAS]
- regulation of membrane potential [IDA]
- regulation of potassium ion transport [IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- alpha-actinin binding [IPI]
- delayed rectifier potassium channel activity [IDA, IMP]
- outward rectifier potassium channel activity [IDA, IMP]
- protein binding [IPI]
- protein kinase binding [IPI]
- scaffold protein binding [IPI]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [IMP]
- alpha-actinin binding [IPI]
- delayed rectifier potassium channel activity [IDA, IMP]
- outward rectifier potassium channel activity [IDA, IMP]
- protein binding [IPI]
- protein kinase binding [IPI]
- scaffold protein binding [IPI]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [IMP]
Gene Ontology Cellular Component
RAB11A
Gene Ontology Biological Process
- GTP catabolic process [IDA, ISO]
- Rab protein signal transduction [IBA]
- astral microtubule organization [ISO]
- establishment of protein localization to membrane [ISO]
- establishment of protein localization to organelle [ISO]
- establishment of vesicle localization [ISO]
- exocytosis [IBA]
- exosomal secretion [ISO]
- intracellular protein transport [IBA]
- melanosome transport [IBA, ISO, ISS]
- mitotic metaphase plate congression [ISO]
- multivesicular body assembly [ISO]
- neuron projection development [ISO, ISS]
- positive regulation of G2/M transition of mitotic cell cycle [ISO]
- positive regulation of axon extension [ISO]
- positive regulation of epithelial cell migration [ISO]
- protein localization to plasma membrane [ISO, ISS]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of multivesicular body size [ISO]
- regulation of protein transport [IMP]
- regulation of vesicle-mediated transport [ISO]
- spindle assembly involved in mitosis [ISO]
- vesicle-mediated transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [ISO]
- cell [ISO]
- cleavage furrow [ISO, ISS]
- cytoplasm [ISO]
- cytoplasmic vesicle [ISO]
- extracellular vesicular exosome [ISO]
- kinetochore microtubule [ISO]
- membrane [ISO]
- mitochondrion [ISO]
- multivesicular body [ISO]
- perinuclear region of cytoplasm [ISO]
- phagocytic vesicle [ISO, ISS]
- protein complex [ISO]
- recycling endosome [IDA, ISO]
- spindle pole [ISO]
- trans-Golgi network [ISO]
- transport vesicle [IDA]
- vesicle [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cholesterol modulates the recruitment of Kv1.5 channels from Rab11-associated recycling endosome in native atrial myocytes.
Cholesterol is an important determinant of cardiac electrical properties. However, underlying mechanisms are still poorly understood. Here, we examine the hypothesis that cholesterol modulates the turnover of voltage-gated potassium channels based on previous observations showing that depletion of membrane cholesterol increases the atrial repolarizing current I(Kur). Whole-cell currents and single-channel activity were recorded in rat adult atrial myocytes (AAM) or ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID