TRIM21
Gene Ontology Biological Process
- innate immune response [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of protein deubiquitination [ISO]
- negative regulation of viral release from host cell [ISO]
- negative regulation of viral transcription [ISO]
- positive regulation of cell cycle [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of viral entry into host cell [IDA]
- protein autoubiquitination [ISO]
- protein destabilization [ISO]
- protein monoubiquitination [ISO]
- protein polyubiquitination [ISO]
- protein trimerization [ISO]
- protein ubiquitination [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FCGR2B
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [IMP]
- cell surface receptor signaling pathway [IMP]
- cellular response to molecule of bacterial origin [IMP]
- defense response [IMP]
- endocytic recycling [ISO]
- immune complex clearance [ISO]
- immune response [IMP]
- immunoglobulin mediated immune response [IMP]
- intracellular signal transduction [TAS]
- mast cell activation [IDA]
- negative regulation of B cell proliferation [IMP]
- negative regulation of acute inflammatory response to antigenic stimulus [IMP]
- negative regulation of humoral immune response mediated by circulating immunoglobulin [IMP]
- negative regulation of immune response [IMP]
- negative regulation of immunoglobulin production [IMP]
- negative regulation of inflammatory response to antigenic stimulus [IMP]
- negative regulation of interleukin-10 production [IMP]
- negative regulation of neutrophil apoptotic process [ISO]
- negative regulation of phagocytosis [IMP]
- negative regulation of type I hypersensitivity [IMP]
- phagocytosis, engulfment [IDA]
- positive regulation of phagocytosis [IDA]
- receptor-mediated endocytosis [ISO]
- response to bacterium [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved.
The newly identified tripartite motif (TRIM) family of proteins mediate innate immunity and other critical cellular functions. Here we show that TRIM21, which mediates the autoimmune diseases rheumatoid arthritis, systemic lupus erythematosus, and Sjoegren's syndrome, is a previously undescribed IgG receptor with a binding mechanism unlike known mammalian Fcgamma receptors. TRIM21 simultaneously targets conserved hot-spot residues on both Ig domains ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TRIM21 FCGR2B | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID