ZBTB16
Gene Ontology Biological Process
- apoptotic process [NAS]
- cartilage development [IDA]
- central nervous system development [ISS]
- hemopoiesis [IDA, TAS]
- mesonephros development [ISS]
- myeloid cell differentiation [TAS]
- negative regulation of myeloid cell differentiation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, NAS]
- positive regulation of cartilage development [IDA]
- positive regulation of chondrocyte differentiation [IMP]
- positive regulation of fat cell differentiation [IMP]
- positive regulation of ossification [IDA]
- positive regulation of transcription, DNA-templated [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, NAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- identical protein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- DNA binding [IDA, NAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- identical protein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
PARP1
Gene Ontology Biological Process
- DNA repair [TAS]
- cellular response to insulin stimulus [IDA]
- double-strand break repair [IMP]
- gene expression [TAS]
- macrophage differentiation [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- protein ADP-ribosylation [IDA]
- protein poly-ADP-ribosylation [IDA]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Proteolytic Processing)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
TIMP-1 regulates cell proliferation by interacting with the ninth zinc finger domain of PLZF.
The tissue inhibitors of metalloproteinases (TIMPs) are multifunctional proteins that specifically inhibit matrix metalloproteinases (MMPs) and regulate extracellular matrix (ECM) turnover and tissue remodeling. This is directed by forming tightly bound inhibitory complexes with MMPs. Recent years have revealed important differences of various biological activities between TIMP families but molecular mechanisms are not clear. To define the molecular mechanisms of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID